肠道微生物群在疾病中对胆汁酸代谢相关信号通路的调控。
Regulation of bile acid metabolism-related signaling pathways by gut microbiota in diseases.
机构信息
State Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, China.
School of Medicine, Southeast University, Nanjing 210097, China.
出版信息
J Zhejiang Univ Sci B. 2019;20(10):781-792. doi: 10.1631/jzus.B1900073.
Abstract
Over the past decade, there has been increasing attention on the interaction between microbiota and bile acid metabolism. Bile acids are not only involved in the metabolism of nutrients, but are also important in signal transduction for the regulation of host physiological activities. Microbial-regulated bile acid metabolism has been proven to affect many diseases, but there have not been many studies of disease regulation by microbial receptor signaling pathways. This review considers findings of recent research on the core roles of farnesoid X receptor (FXR), G protein-coupled bile acid receptor (TGR5), and vitamin D receptor (VDR) signaling pathways in microbial-host interactions in health and disease. Studying the relationship between these pathways can help us understand the pathogenesis of human diseases, and lead to new solutions for their treatments.
摘要
在过去的十年中，人们越来越关注微生物群和胆汁酸代谢之间的相互作用。胆汁酸不仅参与营养物质的代谢，而且在宿主生理活动的信号转导中也起着重要作用。微生物调节的胆汁酸代谢已被证明会影响许多疾病，但关于微生物受体信号通路对疾病调节的研究还很少。本综述考虑了最近关于法尼醇 X 受体 (FXR)、G 蛋白偶联胆汁酸受体 (TGR5)和维生素 D 受体 (VDR)信号通路在健康和疾病中微生物-宿主相互作用中的核心作用的研究结果。研究这些途径之间的关系可以帮助我们了解人类疾病的发病机制，并为其治疗提供新的解决方案。
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