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辐射诱导健康效应的医学对策:美国宇航局人类研究计划研究员研讨会上召开的机构间小组会议的报告,2017 年 1 月 26 日。

Medical countermeasures for radiation induced health effects: report of an Interagency Panel Session held at the NASA Human Research Program Investigator's Workshop, 26 January 2017.

机构信息

NASA Langley Research Center, Hampton, VA, USA.

US Department of Health and Human Services, Biomedical Advanced Research and Development Authority, Office of the Assistant Secretary for Preparedness and Response, Washington, DC, USA.

出版信息

Int J Radiat Biol. 2021;97(sup1):S117-S124. doi: 10.1080/09553002.2019.1665214. Epub 2019 Sep 20.

Abstract

An Interagency Panel Session organized by the NASA Human Research Program (HRP) Space Radiation Program Element (SRPE) was held during the NASA HRP Investigator's Workshop (IWS) in Galveston, Texas on 26 January 2017 to identify complementary research areas that will advance the testing and development of medical countermeasures (MCMs) in support of radioprotection and radiation mitigation on the ground and in space. There were several areas of common interest identified among the various participating agencies. This report provides a summary of the topics discussed by each agency along with potential areas of intersection for mutual collaboration opportunities. Common goals included repurposing of pharmaceuticals, nutraceuticals for use as radioprotectors and/or mitigators, low-dose/chronic exposure paradigms, late effects post-radiation exposure, mixed-field exposures of gamma-neutron, performance decrements, and methods to determine individual exposure levels.

摘要

一个由美国宇航局人类研究计划(HRP)空间辐射计划元素(SRPE)组织的机构间小组会议于 2017 年 1 月 26 日在德克萨斯州加尔维斯顿举行的美国宇航局 HRP 研究员研讨会上举行,旨在确定互补的研究领域,这些领域将推进医疗对策(MCM)的测试和开发,以支持地面和空间的辐射防护和辐射缓解。在各个参与机构中确定了几个共同感兴趣的领域。本报告总结了每个机构讨论的主题,并提供了潜在的交叉合作领域。共同目标包括重新利用药物、作为辐射防护剂和/或缓解剂的营养保健品、低剂量/慢性暴露范式、辐射暴露后的晚期效应、γ-中子混合场暴露、性能下降以及确定个体暴露水平的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6264/8463010/778cf11e18fe/nihms-1734239-f0001.jpg

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