Cao Chen, Zhang Junhui, Yang Chuanhua, Xiang Lili, Liu Wenneng
West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, People's Republic of China.
Onco Targets Ther. 2019 Aug 9;12:6337-6347. doi: 10.2147/OTT.S210618. eCollection 2019.
TiS-HSA-FA, a nanoagent based on titanium disulfide (TiS), human serum albumin (HSA), and folic acid (FA), was synthesized for potential use in synergistic photothermal/radiation therapy for colon cancer.
TiS nanosheets were synthesized through a HSA-assisted exfoliation method and then modified with PEGylated FA. The morphology, size, zeta potential, stability, cellular uptake, cytotoxicity, biodistribution, and in vitro and in vivo biocompatibility of the nanoparticles as well as their suitability for synergistic photothermal/radiation colon cancer therapy were investigated.
The as-synthesized TiS-HSA-FA nanoparticles showed excellent physiological stability, as well as high absorption values in the near-infrared (NIR) and X-ray regions, giving them superb activity as a photothermal and radiation sensitizer. In vitro and in vivo experiments indicated that TiS-HSA-FA showed high tumor targeting selectivity, blood circulation time, biocompatibility, and suitability for synergistic tumor photothermal radiotherapy.
A multifunctional nanoplatform based on TiS was developed and found to be potentially suitable for synergistic photothermal/radiation therapy for colon cancer.
合成了一种基于二硫化钛（TiS）、人血清白蛋白（HSA）和叶酸（FA）的纳米制剂TiS-HSA-FA，用于结肠癌的协同光热/放射治疗。
通过HSA辅助剥离法合成TiS纳米片，然后用聚乙二醇化的FA进行修饰。研究了纳米颗粒的形态、尺寸、zeta电位、稳定性、细胞摄取、细胞毒性、生物分布以及体外和体内生物相容性，以及它们对结肠癌协同光热/放射治疗的适用性。
合成的TiS-HSA-FA纳米颗粒表现出优异的生理稳定性，以及在近红外（NIR）和X射线区域的高吸收值，使其作为光热和放射增敏剂具有卓越的活性。体外和体内实验表明，TiS-HSA-FA具有高肿瘤靶向选择性、血液循环时间、生物相容性，以及适用于协同肿瘤光热放疗。
开发了一种基于TiS的多功能纳米平台，发现其可能适用于结肠癌的协同光热/放射治疗。
