Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Front Immunol. 2019 Aug 21;10:1985. doi: 10.3389/fimmu.2019.01985. eCollection 2019.
A large proportion of the world is inflicted with health concerns arising from infectious diseases. Moreover, there is a widespread emergence of antibiotic resistance among major infectious agents, partially stemming from their continuous dialog with the host, and their enormous capacity to remodel the latter toward a secure niche. Among the several infection-driven events, moderation of WNT signaling pathway has been identified to be strategically tuned during infections to govern host-pathogen interactions. Primarily known for its role in arbitrating early embryonic developmental events; aberrant activation of the WNT pathway has also been associated with immunological consequences during diverse patho-physiological conditions. Here, we review the different mechanisms by which components of WNT signaling pathways are exploited by discrete bacterial agents for their pathogenesis. Furthermore, recent advances on the cross-talk of WNT with other signaling pathways, the varied modes of WNT-mediated alteration of gene expression, and WNT-dependent post-transcriptional and post-translational regulation of the immune landscape during distinct bacterial infections would be highlighted.
世界上很大一部分人都受到传染病引起的健康问题的困扰。此外，主要传染病病原体中的抗生素耐药性广泛出现，部分原因是它们与宿主的持续对话，以及它们巨大的能力将后者重塑为安全的小生境。在几种感染驱动的事件中，WNT 信号通路的调节已被确定在感染过程中被战略性地调整，以控制宿主-病原体相互作用。WNT 途径主要因其在仲裁早期胚胎发育事件中的作用而被熟知；在不同的病理生理条件下，WNT 途径的异常激活也与免疫学后果有关。在这里，我们综述了 WNT 信号通路的不同成分被不同的细菌病原体利用来致病的机制。此外，还将重点介绍 WNT 与其他信号通路的交叉对话、WNT 介导的基因表达改变的不同模式以及在不同细菌感染过程中 WNT 依赖性转录后和翻译后对免疫景观的调节。
