Munk M E, Kaufmann S H
Max-Planck-Institut für Immunobiologie, Freiburg, FRG.
Microb Pathog. 1988 Jul;5(1):49-54. doi: 10.1016/0882-4010(88)90080-0.
Peripheral blood mononuclear cells of healthy individuals were enriched for T lymphocytes and stimulated with killed organisms of Listeria sp. Different strains of Listeria sp. induced comparable T cell responses independent from their pathogenicity and virulence. Evidence is presented that killed L. monocytogenes organisms lacked mitogenic activity for human B and T lymphocytes. It is concluded that Listeria reactive T lymphocytes are commonly present in healthy individuals and hence may contribute to the rare occurrence of listeriosis in normal adults.
健康个体的外周血单个核细胞经富集获得T淋巴细胞，并用李斯特菌属的灭活菌刺激。不同菌株的李斯特菌属诱导出的T细胞反应相当，与其致病性和毒力无关。有证据表明，灭活的单核细胞增生李斯特菌对人B淋巴细胞和T淋巴细胞缺乏促有丝分裂活性。得出的结论是，对李斯特菌有反应的T淋巴细胞普遍存在于健康个体中，因此可能是正常成年人李斯特菌病罕见发生的原因之一。
