Hitit University, Department of Pathology, Faculty of Medicine, 19300 Çorum, Turkey.
University of Health Sciences, Department of Pathology, Haydarpasa Numune Training and Research Hospital, 34668 Istanbul, Turkey.
Pathog Dis. 2019 Jul 1;77(5). doi: 10.1093/femspd/ftz047.
This study aimed to investigate the role of high-risk human papillomavirus (Hr-HPV) in Somalian and Turkish patients with esophageal squamous cell carcinoma (ESCC). In the sections obtained from paraffin-embedded blocks, the results of invasive tumor, peripheral tumor dysplasia and normal mucosa were examined. Samples containing 45 and 47 ESCC, 46 and 42 dysplasia in Somalian (n = 52) and Turkish (n = 53) cases, respectively, were included in the study. We examined the presence of 14 types of Hr-HPV in ESCC collected from Somalia and Turkey by Aptima® Panther System. Hr-HPV types were not detected in Somalian cases. p16INK4a is positive in 5 (11.4%) tumors and 6 (13%) dysplasia. p53 is positive in 28 (62.2%) tumors and 35 (76.1%) dysplasia. HPV16-18/45 are positive only in one of the Turkish cases. p16INK4a is positive in 5 (10.6%) tumors and 4 (9.5%) dysplasia. p53 is positive in 31 (63.3%) tumors and 24 (57.1%) dysplasia. No reaction was detected in normal mucosa samples in both countries. This study is regional. Although the findings did not reflect the general population, the present study shows that the effect of HPV on carcinogenesis in Somalian and Turkish ESCC patients was not significant.
本研究旨在探讨高危型人乳头瘤病毒（Hr-HPV）在索马里和土耳其食管鳞状细胞癌（ESCC）患者中的作用。在石蜡包埋块中获得的切片中，检查了浸润性肿瘤、周围肿瘤异型增生和正常黏膜的结果。研究纳入了 45 例和 47 例索马里（n=52）及土耳其（n=53）ESCC 患者的肿瘤组织，以及 46 例和 42 例异型增生组织。我们使用 Aptima® Panther 系统检测了从索马里和土耳其采集的 ESCC 样本中 14 种 Hr-HPV 的存在情况。在索马里病例中未检测到 Hr-HPV 型。p16INK4a 在 5 例（11.4%）肿瘤和 6 例（13%）异型增生中呈阳性。p53 在 28 例（62.2%）肿瘤和 35 例（76.1%）异型增生中呈阳性。HPV16-18/45 在土耳其的一个病例中呈阳性。p16INK4a 在 5 例（10.6%）肿瘤和 4 例（9.5%）异型增生中呈阳性。p53 在 31 例（63.3%）肿瘤和 24 例（57.1%）异型增生中呈阳性。在两个国家的正常黏膜样本中均未检测到反应。本研究是区域性的。尽管这些发现并不能反映总体人群，但本研究表明 HPV 对索马里和土耳其 ESCC 患者的致癌作用并不显著。
