脑类器官研究的伦理：关注意识。
The Ethics of Cerebral Organoid Research: Being Conscious of Consciousness.
机构信息
Uehiro Research Division for iPS Cell Ethics, Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan; Institute for the Advanced Study of Human Biology (WPI-ASHBi), KUIAS Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
出版信息
Stem Cell Reports. 2019 Sep 10;13(3):440-447. doi: 10.1016/j.stemcr.2019.08.003.
Recently, the use of three-dimensional neural tissues cultured in vitro and called "cerebral organoids" has advanced recapitulation of neural development and disease modeling studies. Along with such advances, cerebral organoid research, and associated concerns call for the elucidation of two points: (1) how cerebral organoid research is currently progressing and the future directions it is likely to take, especially in functional assessment of organoids, and (2) how we should solve ethical issues of possible consciousness in cerebral organoid research. This paper aims first to explore these two issues, and then to present implications and prospects for future cerebral organoid research.
最近，在体外培养的三维神经组织，称为“类脑器官”，已经在神经发育和疾病建模研究中得到了广泛应用。随着这些进展，类脑器官研究及其相关问题需要阐明两个方面：（1）类脑器官研究目前的进展情况和未来可能的发展方向，特别是在类器官的功能评估方面；（2）我们应该如何解决类脑器官研究中可能存在的意识的伦理问题。本文旨在首先探讨这两个问题，然后提出对未来类脑器官研究的启示和展望。
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