Vafaee Reza, Hatamabadi Hamidreza, Soori Hamid, Hedayati Mehdi
Safety Promotion and Injury Prevention Research Center, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Pharm Res. 2019 Spring;18(2):772-784. doi: 10.22037/ijpr.2019.1100684.
Severe physical activity leads to a sharp increase in free radicals, an oxidative stress, inflammation, and tissue damage. Resveratrol as one of the antioxidants can be effective in preventing the effects of oxidative stress. Therefore, the present study was aimed to evaluate the effect of trans-resveratrol supplementation and training exercise on inflammation-related factors. Sixty-four male Wistar rats were divided into six groups, each group consisting of 16 animals: 1) excursive + trans-resveratrol, 2) exercise group, 3) trans-resveratrol group, and 4) control group. Following the familiarization sessions, a more consistent protocol with an intensity of 65% vo2 max was performed for 12 weeks. Afterward, half of the mice in each group received acute exercise training with an intensity of 70-75% of vo2 max at the age of 20 weeks, until reaching the disability level. Finally, the levels of inflammatory markers were measured using special kits. Our findings depicted that inflammatory factors such as CPR, TNF-α, IL-6, and IL-7 were not affected by endurance protocol ( > 0.05), whereas, they were significantly increased by acute exercise training ( > 0.05). Additionally, we found that RES supplements led to a decrease in CPR and IL-6 levels, while not affecting TNF-α and IL-17 levels. According to available evidence, RES appears to have anti-inflammatory and protective effects during exercise by reducing inflammatory factors. Further studies are required to clarify the role of trans-resveratrol supplementation after exercise training.
剧烈的体力活动会导致自由基急剧增加、氧化应激、炎症和组织损伤。白藜芦醇作为抗氧化剂之一，在预防氧化应激的影响方面可能有效。因此，本研究旨在评估反式白藜芦醇补充剂和训练运动对炎症相关因子的影响。将64只雄性Wistar大鼠分为六组，每组16只动物：1）运动+反式白藜芦醇组，2）运动组，3）反式白藜芦醇组，4）对照组。在熟悉训练阶段之后，以65%最大摄氧量的强度进行了为期12周的更一致的训练方案。之后，每组一半的小鼠在20周龄时接受强度为最大摄氧量70 - 75%的急性运动训练，直至达到疲劳水平。最后，使用专用试剂盒测量炎症标志物水平。我们的研究结果表明，诸如CPR、TNF-α、IL-6和IL-7等炎症因子不受耐力训练方案的影响（P>0.05），然而，它们在急性运动训练后显著增加（P>0.05）。此外，我们发现补充白藜芦醇可导致CPR和IL-6水平降低，而对TNF-α和IL-17水平没有影响。根据现有证据，白藜芦醇似乎通过减少炎症因子在运动期间具有抗炎和保护作用。需要进一步的研究来阐明运动训练后补充反式白藜芦醇的作用。
