School of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou 510220, China.
School of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou 510220, China; Guangzhou Key Lab for Efficient Use of Agricultural Chemicals, Guangzhou 510220, China.
Mater Sci Eng C Mater Biol Appl. 2019 Dec;105:110073. doi: 10.1016/j.msec.2019.110073. Epub 2019 Aug 23.
Mesoporous silica nanoparticle (MSN) is a novel vehicle to deliver pesticide. MSN can be modified with different chemical groups to increase its interaction with pesticides. In this study, polydopamine-modified mesoporous silica (MSN-PDA) was prepared through a one-pot method with the addition of dopamine (DA). Copper ions, zinc ions, and iron ions were impregnated on MSN-PDA. In addition, avermectin (AVM) was used as the model drug. We investigated the materials' structure, adsorption and release behaviors, anti-UV properties, as well as their adhesive capability, especially the bridge effect of metal ions, π-π stacking of PDA and electrostatic interaction. The results demonstrated that the above materials possessed spherical morphology with surface areas from 635.833 to 1048.960 m/g. Except for the zinc ions, the complexation with copper and iron ions not only enhanced materials' UV resistance but also increased their adsorption rate and the loading amount of AVM from 133 mg/g to 248 and 243 mg/g, respectively. At pH 3, 7, and 10, the bridge effect of the metal ions demonstrated a cumulative release rate using MSN-PDA not over 30% for AVM in 180 h, while the cumulative release rate for MSN reached its 50% in 60, 90, and 50 h under different pH values, respectively. We further demonstrated that the adhesive effect of PDA could be decreased by metal ions.
介孔硅纳米颗粒（MSN）是一种新型的农药传递载体。可以通过在多巴胺（DA）存在下的一锅法对 MSN 进行修饰，以增加其与农药的相互作用。在这项研究中，通过一锅法制备了聚多巴胺修饰的介孔硅（MSN-PDA），并添加了多巴胺（DA）。将铜离子、锌离子和铁离子浸渍在 MSN-PDA 上。此外，阿维菌素（AVM）被用作模型药物。我们研究了这些材料的结构、吸附和释放行为、抗紫外线性能以及它们的粘附性能，特别是金属离子的桥接效应、PDA 的π-π堆积和静电相互作用。结果表明，上述材料具有球形形貌，比表面积从 635.833 到 1048.960 m/g。除了锌离子之外，铜和铁离子的络合不仅增强了材料的抗紫外线能力，还提高了它们的吸附率和载药量，从 133 mg/g 分别提高到 248 和 243 mg/g。在 pH 3、7 和 10 下，金属离子的桥接效应使载有 AVM 的 MSN-PDA 在 180 h 内的累积释放率不超过 30%，而在不同 pH 值下，载有 AVM 的 MSN 在 60、90 和 50 h 内的累积释放率分别达到 50%。我们进一步证明，金属离子可以降低 PDA 的粘附效果。
