Fitzpatrick Megan B, Thakor Avnesh S
Interventional Regenerative Medicine and Imaging Laboratory, Department of Radiology, Stanford University, Palo Alto, CA 94305, USA.
Stanford Hospitals and Clinics, Department of Pathology, Stanford, CA 94305, USA.
J Clin Med. 2019 Sep 23;8(10):1525. doi: 10.3390/jcm8101525.
During the Dutch winter famine of 1944-1945, an interesting observation was made about the offspring born during this time-They had an increased risk of developing metabolic syndrome and other chronic diseases. Subsequent research has confirmed this finding as well as noting that health outcomes for many diseases are different, and often worse, for women. These findings, combined with the lack of enrollment of women in clinical trials and/or analysis of sex-specific differences are important factors which need to be addressed. In fact, Women's health research and sex differences have historically been overlooked or lumped together and assumed equivalent to those of men. Hence, a focus on women's health and disease prevention is critical to improve the lives of women in the 21st Century. In this review, we point out the critical differences biologically and socially that present both challenges and opportunities for development of novel platforms for precision health. The technologic and scientific advances specific to women's precision health have the potential to improve the health and wellbeing for all females across the world.
在1944 - 1945年荷兰冬季饥荒期间，人们对这一时期出生的后代进行了一项有趣的观察——他们患代谢综合征和其他慢性疾病的风险增加。后续研究证实了这一发现，同时也指出，许多疾病的健康结果在女性中有所不同，而且往往更糟。这些发现，再加上临床试验中女性参与率低和/或对性别差异缺乏分析，都是需要解决的重要因素。事实上，女性健康研究和性别差异在历史上一直被忽视或混为一谈，并被认为与男性的情况相同。因此，关注女性健康和疾病预防对于改善21世纪女性的生活至关重要。在这篇综述中，我们指出了生物学和社会方面的关键差异，这些差异为精准健康新平台的开发带来了挑战和机遇。女性精准健康特有的技术和科学进步有可能改善全世界所有女性的健康和福祉。
