Scolari Francesca, Casiraghi Maurizio, Bonizzoni Mariangela
Department of Biology and Biotechnology, University of Pavia, Pavia, Italy.
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.
Front Microbiol. 2019 Sep 4;10:2036. doi: 10.3389/fmicb.2019.02036. eCollection 2019.
spp. are a major public health concern due to their ability to be efficient vectors of dengue, Chikungunya, Zika, and other arboviruses. With limited vaccines available and no effective therapeutic treatments against arboviruses, the control of spp. populations is currently the only strategy to prevent disease transmission. Host-associated microbes (i.e., microbiota) recently emerged as a promising field to be explored for novel environmentally friendly vector control strategies. In particular, gut microbiota is revealing its impact on multiple aspects of spp. biology, including vector competence, thus being a promising target for manipulation. Here we describe the technological advances, which are currently expanding our understanding of microbiota composition, abundance, variability, and function in the two main arboviral vectors, the mosquitoes and . spp. microbiota is described in light of its tight connections with the environment, with which mosquitoes interact during their various developmental stages. Unraveling the dynamic interactions among the ecology of the habitat, the mosquito and the microbiota have the potential to uncover novel physiological interdependencies and provide a novel perspective for mosquito control.
由于其能够高效传播登革热、基孔肯雅热、寨卡病毒及其他虫媒病毒，[蚊属]物种成为主要的公共卫生问题。鉴于可用疫苗有限且缺乏针对虫媒病毒的有效治疗方法，控制[蚊属]物种数量目前是预防疾病传播的唯一策略。宿主相关微生物（即微生物群）最近成为一个有前景的领域，有望探索新型环保的病媒控制策略。特别是，肠道微生物群正在揭示其对[蚊属]物种生物学多个方面的影响，包括媒介能力，因此是一个有前景的操控靶点。在此，我们描述了一些技术进展，这些进展目前正在扩展我们对两种主要虫媒病毒载体[按蚊属]蚊子和[伊蚊属]蚊子中微生物群组成、丰度、变异性和功能的理解。鉴于[蚊属]物种微生物群与环境的紧密联系，在其不同发育阶段蚊子与环境相互作用，我们对[蚊属]物种微生物群进行了描述。揭示栖息地生态、蚊子和微生物群之间的动态相互作用，有可能发现新的生理相互依存关系，并为蚊子控制提供新的视角。
