Department of Precision Medicine and Healthcare, Tsinghua-Berkeley Shenzhen Institute, Shenzhen 518055, China.
Department of Mechanical Engineering, Biomanufacturing Center, Tsinghua University, Beijing 100084, China.
Mar Drugs. 2019 Sep 28;17(10):555. doi: 10.3390/md17100555.
Three-dimensional (3D) bioprinting has become a flexible tool in regenerative medicine with potential for various applications. Further development of the new 3D bioprinting field lies in suitable bioink materials with satisfied printability, mechanical integrity, and biocompatibility. Natural polymers from marine resources have been attracting increasing attention in recent years, as they are biologically active and abundant when comparing to polymers from other resources. This review focuses on research and applications of marine biomaterials for 3D bioprinting. Special attention is paid to the mechanisms, material requirements, and applications of commonly used 3D bioprinting technologies based on marine-derived resources. Commonly used marine materials for 3D bioprinting including alginate, carrageenan, chitosan, hyaluronic acid, collagen, and gelatin are also discussed, especially in regards to their advantages and applications.
三维(3D)生物打印已成为再生医学中一种灵活的工具,具有多种应用的潜力。新的 3D 生物打印领域的进一步发展在于具有满意的可打印性、机械完整性和生物相容性的合适的生物墨水材料。近年来,海洋资源中的天然聚合物由于与其他资源中的聚合物相比具有生物活性和丰富性,因此受到越来越多的关注。本综述重点介绍了用于 3D 生物打印的海洋生物材料的研究和应用。特别关注了基于海洋衍生资源的常用 3D 生物打印技术的机制、材料要求和应用。还讨论了常用于 3D 生物打印的海洋材料,包括藻酸盐、卡拉胶、壳聚糖、透明质酸、胶原和明胶,特别是它们的优点和应用。