Kadurugamuwa J L, Anwar H, Brown M R, Zak O
Antimicrob Agents Chemother. 1985 Feb;27(2):220-3. doi: 10.1128/AAC.27.2.220.
Subinhibitory MICs (sub-MICs) of several cephalosporins significantly reduced the enterochelin production of Klebsiella pneumoniae 327 grown under iron-depleted conditions and also reduced capsule formation regardless of iron availability. The surface hydrophobicity of K. pneumoniae 327 increased significantly when the bacteria were grown in either iron-sufficient or iron-depleted media in the presence of sub-MICs of all the cephalosporins used in this study. Antisera raised against a non-encapsulated K. pneumoniae strain caused rapid agglutination of K. pneumoniae 327 grown in the presence of sub-MICs of the cephalosporins but no agglutination of the same strain grown in drug-free media. The results indicated that the cephalosporins reduced enterochelin production and also capsule formation to the extent that noncapsular surface antigens were exposed, with possible significant consequences in vivo.
几种头孢菌素的亚抑菌浓度（亚 MIC）显著降低了在缺铁条件下生长的肺炎克雷伯菌 327 的肠螯合素产量，并且无论铁的可用性如何，也降低了荚膜形成。当细菌在本研究中使用的所有头孢菌素的亚 MIC 存在下于铁充足或缺铁培养基中生长时，肺炎克雷伯菌 327 的表面疏水性显著增加。针对非包膜肺炎克雷伯菌菌株产生的抗血清导致在头孢菌素亚 MIC 存在下生长的肺炎克雷伯菌 327 快速凝集，但在无药物培养基中生长的同一菌株不发生凝集。结果表明，头孢菌素降低了肠螯合素产量以及荚膜形成，以至于非荚膜表面抗原暴露，这在体内可能产生重大后果。
