College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Department of Endocrinology, The First Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.
PLoS One. 2024 Nov 14;19(11):e0310732. doi: 10.1371/journal.pone.0310732. eCollection 2024.
Diabetic peripheral neuropathy (DPN), a prevalent complication among individuals diagnosed with type 2 diabetes, has a significant impact on both the well-being of patients and their financial situation. Acupuncture has been employed for thousands of years within China and is regarded as one of the primary characteristic therapies of traditional Chinese medicine. Research has indicated that acupuncture has the potential to enhance microcirculation, decrease the generation of free radicals, and augment nerve conduction velocity. There had been several meta-analyses of acupuncture on DPN. Nevertheless, there has been inadequate attention given to the assessment of blood glucose control, and scores related to quality of life. Hence, we get additional evidence by enhancing the quantity and quality of studies to draw more distinct findings.
We will conduct a comprehensive search for reports published from the beginning until June 2023 using various databases including Web of Science, Embase, Cochrane Library, PubMed, AMED, Wanfang database, VIP database, China National Knowledge Infrastructure, and Chinese Biomedical Literature database. Only randomized controlled trials will be considered, with no exclusion of quasi-randomized control trials. Articles in both English and Chinese will be taken into account without any limitations on publication dates. The data will be extracted, managed, and analyzed by two researchers working independently. The primary outcomes will include improvement of symptom scores, change of nerve conduction velocity, and quality of life scores. Additional outcomes will encompass blood glucose levels after fasting and 2 hours after eating, levels of glycosylated hemoglobin, and any adverse events associated with acupuncture. We plan to use the RevMan V.5.4 application and the random-effects model for conducting the meta-analysis. The assessment of potential prejudice can be conducted by Cochrane's 'risk of bias' 2 (RoB 2) tool. Registration: PROSPERO (registration number: CRD42023425203).
Our goal is to perform a meta-analysis that offers an unbiased approach to treating individuals with type 2 DPN. At the same time, it also provides doctors with more choices in the treatment of diabetes peripheral neuropathy.
糖尿病周围神经病变（DPN）是 2 型糖尿病患者常见的并发症，对患者的健康和经济状况都有重大影响。在中国，针灸已经应用了几千年，被认为是中医的主要特色疗法之一。研究表明，针灸具有改善微循环、减少自由基生成和提高神经传导速度的作用。已经有几项关于针灸治疗 DPN 的荟萃分析，但对血糖控制和生活质量评分的评估关注不足。因此，我们通过增加研究数量和质量来获得更多证据，以得出更明确的发现。
我们将全面检索从开始到 2023 年 6 月发表的报告，使用各种数据库，包括 Web of Science、Embase、Cochrane Library、PubMed、AMED、万方数据库、维普数据库、中国知识基础设施和中国生物医学文献数据库。仅考虑随机对照试验，不排除半随机对照试验。将考虑中英文文章，不限制出版日期。由两名独立研究人员提取、管理和分析数据。主要结局将包括症状评分的改善、神经传导速度的变化和生活质量评分的变化。其他结局将包括空腹和餐后 2 小时血糖水平、糖化血红蛋白水平以及与针灸相关的任何不良事件。我们计划使用 RevMan V.5.4 应用程序和随机效应模型进行荟萃分析。潜在偏见的评估可以使用 Cochrane 的“风险偏倚”2（RoB 2）工具进行。注册：PROSPERO（注册号：CRD42023425203）。
我们的目标是进行一项荟萃分析，为 2 型 DPN 患者提供一种无偏倚的治疗方法，同时为医生在治疗糖尿病周围神经病变方面提供更多选择。
