培氟沙星和环丙沙星在实验性诱导的中性粒细胞减少豚鼠假单胞菌肺炎中的活性。
Activities of pefloxacin and ciprofloxacin in experimentally induced Pseudomonas pneumonia in neutropenic guinea pigs.
作者信息
Gordin F M, Hackbarth C J, Scott K G, Sande M A
出版信息
Antimicrob Agents Chemother. 1985 Apr;27(4):452-4. doi: 10.1128/AAC.27.4.452.
Abstract
Pefloxacin and ciprofloxacin are two new quinoline carboxylic acid derivatives that have activity in vitro against a wide range of gram-negative bacteria, including Pseudomonas aeruginosa. Using a well-standardized model of Pseudomonas pneumonia in neutropenic guinea pigs, we tested the efficacy in vivo of these new agents. Both were highly effective in increasing survival and decreasing bacterial counts in the lungs of surviving animals. Pefloxacin and ciprofloxacin were significantly better (P less than 0.05) than aminoglycosides or beta-lactams tested in prior studies with this model, and they were as effective as combination therapy with aminoglycosides and beta-lactams. Resistance to either ciprofloxacin or pefloxacin did not emerge during the study period. Further studies with these drugs in the therapy of Pseudomonas sp. infections are warranted.
摘要
培氟沙星和环丙沙星是两种新型喹啉羧酸衍生物，它们在体外对包括铜绿假单胞菌在内的多种革兰氏阴性菌具有活性。我们使用中性粒细胞减少的豚鼠中标准化良好的铜绿假单胞菌肺炎模型，测试了这些新药的体内疗效。两者在提高存活率和降低存活动物肺部细菌数量方面都非常有效。在该模型的先前研究中，培氟沙星和环丙沙星显著优于（P小于0.05）所测试的氨基糖苷类或β-内酰胺类药物，并且它们与氨基糖苷类和β-内酰胺类药物联合治疗的效果相同。在研究期间未出现对环丙沙星或培氟沙星的耐药性。有必要对这些药物在治疗铜绿假单胞菌感染方面进行进一步研究。
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