Hilton J M, Ison C A, Easmon C S
Genitourin Med. 1985 Aug;61(4):241-3. doi: 10.1136/sti.61.4.241.
A concentration of 16 mg/l spectinomycin incorporated in agar gave the best discrimination between Neisseria gonorrhoeae sensitive and resistant to spectinomycin. This method was compared with spectinomycin sensitivity testing with 25 micrograms or 100 micrograms discs. Both methods agreed fully for 197 spectinomycin sensitive and three spectinomycin resistant gonococci. The agar incorporation "breakpoint" concentration technique failed to detect a small spectinomycin resistant population in a fourth isolate, which was detected by disc testing. It may be possible to predict the emergence of spectinomycin resistance among strains of N gonorrhoeae.
在琼脂中加入浓度为16毫克/升的壮观霉素，能最佳地区分对壮观霉素敏感和耐药的淋病奈瑟菌。该方法与使用含25微克或100微克壮观霉素纸片的壮观霉素敏感性试验进行了比较。对于197株对壮观霉素敏感和3株对壮观霉素耐药的淋球菌，两种方法的结果完全一致。琼脂掺入“断点”浓度技术未能检测出第四株分离菌中的一小部分对壮观霉素耐药的菌群，而纸片试验检测到了该菌群。也许有可能预测淋病奈瑟菌菌株中壮观霉素耐药性的出现。
