Department of Genetics, Stanford University, Palo Alto, CA 94304-5477, USA.
Oregon Health Sciences University, Portland, OR 97239, USA.
Nucleic Acids Res. 2020 Jan 8;48(D1):D743-D748. doi: 10.1093/nar/gkz892.
The Saccharomyces Genome Database (SGD; www.yeastgenome.org) maintains the official annotation of all genes in the Saccharomyces cerevisiae reference genome and aims to elucidate the function of these genes and their products by integrating manually curated experimental data. Technological advances have allowed researchers to profile RNA expression and identify transcripts at high resolution. These data can be configured in web-based genome browser applications for display to the general public. Accordingly, SGD has incorporated published transcript isoform data in our instance of JBrowse, a genome visualization platform. This resource will help clarify S. cerevisiae biological processes by furthering studies of transcriptional regulation, untranslated regions, genome engineering, and expression quantification in S. cerevisiae.
酿酒酵母基因组数据库（SGD；www.yeastgenome.org）维护着酿酒酵母参考基因组中所有基因的官方注释，并通过整合精心编辑的实验数据来阐明这些基因及其产物的功能。技术进步使得研究人员能够对 RNA 表达进行分析，并以高分辨率鉴定转录本。这些数据可以在基于网络的基因组浏览器应用程序中进行配置，以便向公众展示。因此，SGD 在我们的 JBrowse 实例中整合了已发表的转录本异构体数据，JBrowse 是一个基因组可视化平台。该资源将通过进一步研究转录调控、非翻译区、基因组工程和酿酒酵母表达定量，帮助阐明酿酒酵母的生物学过程。
