Mantha Somasundar, Pillai Sangeeth, Khayambashi Parisa, Upadhyay Akshaya, Zhang Yuli, Tao Owen, Pham Hieu M, Tran Simon D
McGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dentistry, McGill University, 3640 University Street, Montreal, QC H3A 0C7, Canada.
Materials (Basel). 2019 Oct 12;12(20):3323. doi: 10.3390/ma12203323.
The field of regenerative medicine has tremendous potential for improved treatment outcomes and has been stimulated by advances made in bioengineering over the last few decades. The strategies of engineering tissues and assembling functional constructs that are capable of restoring, retaining, and revitalizing lost tissues and organs have impacted the whole spectrum of medicine and health care. Techniques to combine biomimetic materials, cells, and bioactive molecules play a decisive role in promoting the regeneration of damaged tissues or as therapeutic systems. Hydrogels have been used as one of the most common tissue engineering scaffolds over the past two decades due to their ability to maintain a distinct 3D structure, to provide mechanical support for the cells in the engineered tissues, and to simulate the native extracellular matrix. The high water content of hydrogels can provide an ideal environment for cell survival, and structure which mimics the native tissues. Hydrogel systems have been serving as a supportive matrix for cell immobilization and growth factor delivery. This review outlines a brief description of the properties, structure, synthesis and fabrication methods, applications, and future perspectives of smart hydrogels in tissue engineering.
再生医学领域在改善治疗效果方面具有巨大潜力，并且在过去几十年中受到生物工程学进展的推动。工程化组织和组装能够恢复、保留和振兴受损组织与器官的功能性构建体的策略，已经影响到了整个医学和医疗保健领域。将仿生材料、细胞和生物活性分子相结合的技术，在促进受损组织再生或作为治疗系统方面起着决定性作用。在过去二十年中，水凝胶因其能够维持独特的三维结构、为工程组织中的细胞提供机械支持以及模拟天然细胞外基质，而被用作最常见的组织工程支架之一。水凝胶的高含水量可为细胞存活提供理想环境，其结构可模拟天然组织。水凝胶系统一直作为细胞固定和生长因子递送的支持性基质。本文综述简要介绍了智能水凝胶在组织工程中的性质、结构、合成与制备方法、应用以及未来展望。
