Banerji A P, Dutta S
Endocrinol Exp. 1979;13(4):217-23.
Peroxidase activity and its inducibility by estrogen in the uterine and breast tissues of Holtzman rats varied with the age of animals. Basal proxidase level of the two tissues was low in immature and high in older animals. Estrogen induced significant peroxidase activity in the uteri of rats up to 56 days of age and thereafter the uterine response was poor. Though the breast tissue peroxidase response to estrogen was significant in 20-160 days old female rats, greater inducibility being noted between 40-90 days of age. Among the sex steroids, only estrogen could induce the enzyme in the breast tissue in a dose dependent way. Peroxidase was also induced appreciably in the male breast tissue to an extent observed in age-matched females. It is suggested that this enzyme could be regarded as a diagnostic end point of estrogen action in the rat breast tissue.
霍尔兹曼大鼠子宫和乳腺组织中的过氧化物酶活性及其对雌激素的诱导性随动物年龄而变化。这两种组织的基础过氧化物酶水平在未成熟动物中较低，而在老年动物中较高。雌激素在56日龄以下的大鼠子宫中诱导出显著的过氧化物酶活性，此后子宫反应较差。虽然乳腺组织对雌激素的过氧化物酶反应在20 - 160日龄的雌性大鼠中显著，在40 - 90日龄之间诱导性更强。在性类固醇中，只有雌激素能以剂量依赖的方式在乳腺组织中诱导该酶。过氧化物酶在雄性乳腺组织中也有明显诱导，其程度与年龄匹配的雌性动物中观察到的相似。有人提出，这种酶可被视为大鼠乳腺组织中雌激素作用的诊断终点。
