Zhang Meng, Xu Gezhi, Wang Xin, Ni Yingqin, Huang Xin
Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai 200031, People's Republic of China.
Institute of Eye Research, Eye and ENT Hospital of Fudan University, Shanghai 200031, People's Republic of China.
Risk Manag Healthc Policy. 2020 Dec 7;13:2867-2873. doi: 10.2147/RMHP.S282102. eCollection 2020.
To investigate the incidence and clinical characteristics of ROP in extremely preterm (EP) and extremely low birth weight (ELBW) infants in eastern China.
This retrospective study included 104 infants with a birth weight (BW) ≤ 1000 g and gestational age (GA) ≤ 28 weeks, who were admitted to the Eye and ENT Hospital of Fudan University over 10 years. The infants were examined for ROP with RetCam. Infants with type 1 ROP and aggressive posterior ROP (AP-ROP) were treated. The risk factors evaluated were GA and BW.
Mean GA was 26.63 ± 0.88 weeks and mean BW was 892.39 ± 108.06 g. Of the 104 infants, 83 (79.8%) developed ROP, three (2.9%) had AP-ROP, 14 (13.5%) had type 1 ROP, and 10 (9.6%) had type 2 ROP. The proportions of infants with BW ≤750 g and 751-1000 g were 8.7% and 91.3%, respectively, and the incidences of severe ROP in these infants were 22.2% and 15.8%, respectively. The infants with severe ROP had a mean GA of 26.56 ± 0.68 weeks and mean BW of 860.00 ± 163.48 g, and 47.1% of severe ROP occurred in infants with a GA of 26 weeks. However, multivariate logistic regression showed that the severity of ROP was not directly inversely related to GA or BW in this study population.
In EP and ELBW Chinese infants, who were admitted to the Eye and ENT Hospital of Fudan University, the development of ROP was more frequent and the incidence of severe ROP that progressed to the stage that required treatment was high.
调查中国东部极早产儿（EP）和极低出生体重儿（ELBW）中视网膜病变（ROP）的发病率及临床特征。
这项回顾性研究纳入了10年间复旦大学附属眼耳鼻喉科医院收治的104例出生体重（BW）≤1000g且胎龄（GA）≤28周的婴儿。使用RetCam对婴儿进行ROP检查。对1型ROP和侵袭性后部ROP（AP-ROP）患儿进行治疗。评估的危险因素为GA和BW。
平均GA为26.63±0.88周，平均BW为892.39±108.06g。104例婴儿中，83例（79.8%）发生ROP，3例（2.9%）为AP-ROP，14例（13.5%）为1型ROP，10例（9.6%）为2型ROP。BW≤750g和751 - 1000g的婴儿比例分别为8.7%和91.3%，这些婴儿中重度ROP的发生率分别为22.2%和15.8%。重度ROP婴儿的平均GA为26.56±0.68周，平均BW为860.00±163.48g，47.1%的重度ROP发生在GA为26周的婴儿中。然而，多因素逻辑回归显示，在该研究人群中，ROP的严重程度与GA或BW并无直接的反向关系。
在复旦大学附属眼耳鼻喉科医院收治的中国EP和ELBW婴儿中，ROP的发生更为频繁，进展到需要治疗阶段的重度ROP发生率较高。
