Liu Pan, Zhang Yaxin, Ma Lina
Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.
J Int Med Res. 2019 Nov;47(11):5465-5474. doi: 10.1177/0300060519882570. Epub 2019 Oct 30.
Telomeres and telomerase play important roles in the occurrence and development of hypertension. This review was performed to clarify the factors that influence telomere length and telomerase activity in older patients and elucidate the association of these factors with hypertension. A PubMed search and critical review of studies assessing the risk factors underlying the association of hypertension with telomere length and telomerase activity was performed. Telomere length and telomerase activity were found to be associated with hypertension. The factors that influence telomere length and telomerase activity in older patients with hypertension include genetics, demographics, social and environmental factors, chronic disease, psychological factors, and antihypertensive drug treatment. A better understanding of the molecular mechanisms underlying the association of hypertension with telomere length and telomerase activity may help to reduce the incidence of hypertension.
端粒和端粒酶在高血压的发生和发展中起重要作用。本综述旨在阐明影响老年患者端粒长度和端粒酶活性的因素，并阐明这些因素与高血压的关联。我们在PubMed上进行了检索，并对评估高血压与端粒长度及端粒酶活性关联的潜在危险因素的研究进行了批判性综述。结果发现端粒长度和端粒酶活性与高血压有关。影响老年高血压患者端粒长度和端粒酶活性的因素包括遗传学、人口统计学、社会和环境因素、慢性病、心理因素以及降压药物治疗。更好地理解高血压与端粒长度和端粒酶活性关联的分子机制可能有助于降低高血压的发病率。
