First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Aghia Sophia Hospital, Athens, Greece
Department of Oral and Maxillofacial Surgery, School of Medicine, National and Kapodistrian University of Athens, Attikon Hospital, Athens, Greece.
In Vivo. 2019 Nov-Dec;33(6):1751-1755. doi: 10.21873/invivo.11665.
Animal models are valuable tools for studying human cancer as well as for preclinical trials. The hamster model of chemically induced sequential oral carcinogenesis was developed by our group a decade ago in order to study the multistep process of alterations in gene expression during carcinogenesis. The purpose of this review was to discuss the utility of the hamster model of sequential oral carcinogenesis regarding the deciphering of the main pathways altered. An extended search for articles that cited that specific animal models was performed. Many studies have used the hamster model of sequential oral carcinogenesis either for evaluation of the expression of biomarkers alone, or for applying chemopreventive compounds and other therapeutic methods, or combining the use of biomarkers with the anticancer effect of some compounds. It seems that this animal model is indeed a useful tool that enables the study of cell biology, pathology and therapeutics of oral cancer.
动物模型是研究人类癌症以及临床前试验的有价值的工具。我们小组十年前开发了化学诱导序贯口腔致癌的仓鼠模型，以便研究致癌过程中基因表达变化的多步骤过程。本综述的目的是讨论序贯口腔致癌的仓鼠模型在破译主要改变途径方面的应用。我们对引用该特定动物模型的文章进行了广泛的搜索。许多研究都使用了序贯口腔致癌的仓鼠模型，要么单独评估生物标志物的表达，要么应用化学预防化合物和其他治疗方法，要么将生物标志物的使用与某些化合物的抗癌效果结合起来。似乎这种动物模型确实是一种有用的工具，可以研究口腔癌的细胞生物学、病理学和治疗学。
