National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Veterinary Microbiology & Preventative Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Antiviral Res. 2019 Dec;172:104640. doi: 10.1016/j.antiviral.2019.104640. Epub 2019 Oct 25.
The Biosafety Level 4 Zoonotic Laboratory Network (BSL4ZNet) was established in 2016, to provide a means of communication and support for the global high-containment laboratory community. Its working groups focus on international response, institutional cooperation and knowledge sharing, scientific excellence and training. In the latter role, BSL4ZNet sponsored its first international workshop in February 2018, held at the USDA National Centers for Animal Health, Ames, Iowa, USA, focused on necropsy procedures in high-containment laboratories. A second workshop, in November 2018, was held at the National Microbiology Laboratories (CFIA/PHAC) in Winnipeg, Canada, and focused on decontamination. A third workshop, held at the Australian Animal Health Laboratory in Geelong, Australia, in February 2019, was devoted to handling methods and ethical concerns for live animals in high-containment laboratories. The third workshop brought together 12 laboratorians from seven partner organizations in Australia, Canada, Germany, the United Kingdom and the United States. It included both discussion-based and hands-on training sessions on animal welfare, animal models, site-specific infrastructure constraints, health monitoring and humane endpoints, sampling procedures, and carcass disposal. This report summarizes the inception, development, and structure of the BSL4ZNet, and highlights the aims and results of the Geelong workshop.
BSL4ZNet 于 2016 年成立，旨在为全球高生物安全实验室社区提供沟通和支持的途径。其工作组的重点包括国际应对、机构合作和知识共享、科学卓越和培训。在后一个角色中，BSL4ZNet 于 2018 年 2 月在美国爱荷华州艾姆斯的美国农业部国家动物健康中心举办了其首次国际研讨会，该研讨会专注于高生物安全实验室中的剖检程序。第二次研讨会于 2018 年 11 月在加拿大温尼伯的加拿大食品检验署/加拿大卫生部国家微生物学实验室举行，重点是消毒。第三次研讨会于 2019 年 2 月在澳大利亚吉朗的澳大利亚动物健康实验室举行，重点是高生物安全实验室中活体动物的处理方法和伦理问题。第三次研讨会汇集了来自澳大利亚、加拿大、德国、英国和美国的七个合作组织的 12 名实验室人员。它包括动物福利、动物模型、特定地点基础设施限制、健康监测和人道终点、采样程序和尸体处理方面的基于讨论和实践培训课程。本报告总结了 BSL4ZNet 的成立、发展和结构，并重点介绍了吉朗研讨会的目标和结果。
