3-酮脂酰-ACP合酶（KAS）III同源物及其在天然产物生物合成中的作用。
3-Ketoacyl-ACP synthase (KAS) III homologues and their roles in natural product biosynthesis.
作者信息
Nofiani Risa, Philmus Benjamin, Nindita Yosi, Mahmud Taifo
机构信息
Department of Pharmaceutical Sciences , Oregon State University , Corvallis , OR 97333 , USA . Email:
Department of Chemistry , Universitas Tanjungpura , Pontianak , Indonesia.
出版信息
Medchemcomm. 2019 Apr 29;10(9):1517-1530. doi: 10.1039/c9md00162j. eCollection 2019 Sep 1.
Abstract
The 3-ketoacyl-ACP synthase (KAS) III proteins are one of the most abundant enzymes in nature, as they are involved in the biosynthesis of fatty acids and natural products. KAS III enzymes catalyse a carbon-carbon bond formation reaction that involves the α-carbon of a thioester and the carbonyl carbon of another thioester. In addition to the typical KAS III enzymes involved in fatty acid and polyketide biosynthesis, there are proteins homologous to KAS III enzymes that catalyse reactions that are different from that of the traditional KAS III enzymes. Those include enzymes that are responsible for a head-to-head condensation reaction, the formation of acetoacetyl-CoA in mevalonate biosynthesis, tailoring processes C-O bond formation or esterification, as well as amide formation. This review article highlights the diverse reactions catalysed by this class of enzymes and their role in natural product biosynthesis.
摘要
3-酮酰基-ACP合成酶（KAS）III蛋白是自然界中含量最丰富的酶之一，因为它们参与脂肪酸和天然产物的生物合成。KAS III酶催化一种碳-碳键形成反应，该反应涉及硫酯的α-碳和另一种硫酯的羰基碳。除了参与脂肪酸和聚酮生物合成的典型KAS III酶外，还有与KAS III酶同源的蛋白质，它们催化的反应不同于传统KAS III酶。这些酶包括负责头对头缩合反应的酶、甲羟戊酸生物合成中乙酰乙酰辅酶A的形成、修饰过程中碳-氧键的形成或酯化以及酰胺的形成。这篇综述文章强调了这类酶催化的各种反应及其在天然产物生物合成中的作用。
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