IgA肾病患者中IgA特异性抑制性T细胞活性降低。
Decrease of IgA-specific suppressor T cell activity in patients with IgA nephropathy.
作者信息
Sakai H, Nomoto Y, Arimori S
出版信息
Clin Exp Immunol. 1979 Nov;38(2):243-8.
Abstract
The activity of IgA-specific suppressor T cells was lower in eight patients with IgA nephropathy than in six patients with chronic proliferative glomerulonephritis without glomerular deposition of IgA, two patients with acute glomerulonephritis, or five healthy adult controls. It was determined by the quantitation of immunoglobulins produced from pokeweed mitogen-stimulated B cells cultured with the T cell supernatant (TCS) obtained from concanavalin A-stimulated T cells. Results from a study on an identical twin sister with IgA nephropathy suggested that the decreased activity of IgA-specific suppressor T cells might not be a cause but a result of increased IgA-bearing lymphocytes and serum IgA in patients with IgA nephropathy.
摘要
8例IgA肾病患者的IgA特异性抑制性T细胞活性低于6例无IgA肾小球沉积的慢性增殖性肾小球肾炎患者、2例急性肾小球肾炎患者或5名健康成人对照者。通过对用伴刀豆球蛋白A刺激的T细胞获得的T细胞上清液（TCS）培养的商陆有丝分裂原刺激的B细胞产生的免疫球蛋白进行定量来确定。对一名患有IgA肾病的同卵双胞胎姐妹的研究结果表明，IgA特异性抑制性T细胞活性降低可能不是IgA肾病患者携带IgA的淋巴细胞和血清IgA增加的原因，而是其结果。
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