Department of Psychology, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Duke University, Durham, NC 27708-0086, USA.
Neuroimage Clin. 2019;24:102050. doi: 10.1016/j.nicl.2019.102050. Epub 2019 Oct 23.
Childhood adversity is associated with a wide range of negative behavioral and neurodevelopmental consequences. However, individuals vary substantially in their sensitivity to such adversity. Here, we examined how individual variability in structural features of the corticolimbic circuit, which plays a key role in emotional reactivity, moderates the association between childhood adversity and later trait anxiety in 798 young adult university students. Consistent with prior research, higher self-reported childhood adversity was significantly associated with higher self-reported trait anxiety. However, this association was attenuated in participants with higher microstructural integrity of the uncinate fasciculus and greater thickness of the orbitofrontal cortex. These structural properties of the corticolimbic circuit may capture a neural profile of relative resiliency to early life stress, especially against the negative effects of childhood adversity on later trait anxiety.
童年逆境与广泛的负面行为和神经发育后果有关。然而，个体对这种逆境的敏感性有很大的差异。在这里，我们研究了在 798 名年轻成年大学生中，作为情绪反应关键作用的皮质边缘回路的结构特征的个体差异如何调节童年逆境与后期特质焦虑之间的关联。与先前的研究一致，较高的自我报告的童年逆境与较高的自我报告的特质焦虑显著相关。然而，在钩束微观结构完整性较高和眶额皮质厚度较大的参与者中，这种关联减弱了。皮质边缘回路的这些结构特性可能反映了对早期生活压力的相对恢复力的神经特征，尤其是对童年逆境对后期特质焦虑的负面影响的抵抗力。
