Maquart F X, Pickart L, Laurent M, Gillery P, Monboisse J C, Borel J P
Laboratoire de Biochimie, CNRS URA 84, Faculté de Médecine, Reims, France.
FEBS Lett. 1988 Oct 10;238(2):343-6. doi: 10.1016/0014-5793(88)80509-x.
Glycyl-L-histidyl-L-lysine (GHK) is a tripeptide with affinity for copper(II) ions and was isolated from human plasma. This peptide appears to play a physiological role in wound healing. We report the stimulating effect of GHK-Cu on collagen synthesis by fibroblasts. The stimulation began between 10(-12) and 10(-11) M, maximized at 10(-9) M, and was independent of any change in cell number. The presence of a GHK triplet in the alpha 2(I) chain of type I collagen suggests that the tripeptide might be liberated by proteases at the site of a wound and exert in situ healing effects.
甘氨酰-L-组氨酰-L-赖氨酸（GHK）是一种对铜（II）离子具有亲和力的三肽，它是从人血浆中分离出来的。这种肽似乎在伤口愈合中发挥生理作用。我们报告了GHK-Cu对成纤维细胞胶原蛋白合成的刺激作用。这种刺激在10^(-12)至10^(-11)M之间开始，在10^(-9)M时达到最大值，并且与细胞数量的任何变化无关。I型胶原蛋白α2（I）链中存在GHK三联体表明，该三肽可能在伤口部位被蛋白酶释放，并发挥原位愈合作用。
