International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.
Institute of Embryo-Fetal Original Adult Disease, Shanghai Key Laboratory for Reproductive Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.
Sci China Life Sci. 2020 Jun;63(6):898-904. doi: 10.1007/s11427-018-9593-8. Epub 2019 Nov 5.
We conducted a retrospective cohort study of 9,552 women experiencing their second delivery between 2014 and 2016 at the International Peace Maternity and Child Health Hospital to investigate the association between the interpregnancy interval (IPI) and adverse perinatal outcomes. With the 12-23-mon IPI as the reference category, logistic regression analyzes were used to examine associations between different IPIs (<12, 12-23, 24-59, 60-119, and ≥120 mon) and perinatal outcomes (gestational diabetes mellitus, premature membrane rupture, gestational hypertension, preterm birth, low birth weight, and macrosomia). Compared with the 12-23-mon IPI category, women with longer IPIs had a higher risk of adverse perinatal outcomes, and those with an IPI ≥120 mon had the highest risk of gestational diabetes mellitus and premature membrane rupture (adjusted odds ratio (OR) 1.76, 95% confidence interval (CI) 1.32-2.35 and adjusted OR 2.03, 95% CI 1.53-2.67, respectively). These results indicate that a longer IPI is associated with a higher risk of adverse perinatal outcomes and an IPI of ≥120 mon appears to be independently associated with a higher risk of gestational diabetes mellitus and premature membrane rupture.
我们对 2014 年至 2016 年在国际和平妇幼保健院分娩的 9552 名经历第二次分娩的女性进行了回顾性队列研究，以调查妊娠间隔（interpregnancy interval，IPI）与不良围产结局之间的关系。以 12-23 个月的 IPI 为参考类别，使用逻辑回归分析来检查不同 IPI（<12、12-23、24-59、60-119 和≥120 个月）与围产结局（妊娠期糖尿病、胎膜早破、妊娠期高血压、早产、低出生体重和巨大儿）之间的关系。与 12-23 个月的 IPI 类别相比，较长 IPI 的女性发生不良围产结局的风险更高，而 IPI≥120 个月的女性发生妊娠期糖尿病和胎膜早破的风险最高（调整后的优势比（adjusted odds ratio，aOR）1.76，95%置信区间（confidence interval，CI）1.32-2.35 和调整后的 aOR 2.03，95%CI 1.53-2.67）。这些结果表明，较长的 IPI 与不良围产结局的风险增加相关，而 IPI≥120 个月似乎与妊娠期糖尿病和胎膜早破的风险增加独立相关。
