Division of Gynecologic Oncology, Department of Gynecology and Obstetrics, University Hospitals Leuven, Herestraat 49, 3000, Leuven, European Union, Belgium.
Department of Gynecology, Klinikum Klagenfurt, Klagenfurt, European Union, Austria.
J Ovarian Res. 2019 Nov 8;12(1):105. doi: 10.1186/s13048-019-0577-2.
Epithelial ovarian cancer (EOC) remains the most lethal gynecological cancer in developed countries, indicating the need for further research. Although current cancer models prove useful, they have major limitations. Organoids, a novel in vitro 3D cell culture technique, derived from stem cells, could provide a bridge between the current preclinical platforms. However, this technique is still in its early stages. After conducting a systematic literature search, only sixteen manuscripts concerning ovarian related organoids could be retrieved.In this review, we discuss current tumor models, including organoids and provide a comprehensive review about organoids of ovarian tissue. Potential future applications are addressed, proving organoids to be an interesting platform for modeling tumorigenesis, drug testing and screening and other applications. Recent advancements could usher in a new era of highly personalized medicine in EOC.
上皮性卵巢癌 (EOC) 仍然是发达国家最致命的妇科癌症，这表明需要进一步研究。尽管目前的癌症模型证明是有用的，但它们有很大的局限性。类器官，一种源自干细胞的新型体外 3D 细胞培养技术，可以在当前的临床前平台之间架起桥梁。然而，这项技术仍处于早期阶段。通过进行系统的文献检索，仅检索到 16 篇关于卵巢相关类器官的手稿。在这篇综述中，我们讨论了当前的肿瘤模型，包括类器官，并对卵巢组织的类器官进行了全面的综述。探讨了潜在的未来应用，证明类器官是肿瘤发生、药物测试和筛选以及其他应用的建模的一个有趣平台。最近的进展可能会开创上皮性卵巢癌高度个性化医疗的新时代。
