Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, location AMC, Meibergdreef 9, Room G1-226, 1105 AZ, Amsterdam, The Netherlands.
Amsterdam University Medical Centers, Department of Pediatric Hematology, Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital, Amsterdam, The Netherlands.
Pediatr Radiol. 2020 Mar;50(3):371-379. doi: 10.1007/s00247-019-04557-4. Epub 2019 Nov 9.
Ongoing arthritis in children with juvenile idiopathic arthritis (JIA) can result in cartilage damage.
To study the feasibility and repeatability of T for assessing knee cartilage in JIA and also to describe T values and study correlation between T and conventional MRI scores for disease activity.
Thirteen children with JIA or suspected JIA underwent 3-tesla (T) knee MRI that included conventional sequences and a T sequence. Segmentation of knee cartilage was carried out on T images. We used intraclass correlation coefficient to study the repeatability of segmentation in a subset of five children. We used the juvenile arthritis MRI scoring system to discriminate inflamed from non-inflamed knees. The Mann-Whitney U and Spearman correlation compared T between children with and without arthritis on MRI and correlated T with the juvenile arthritis MRI score.
All children successfully completed the MRI examination. No images were excluded because of poor quality. Repeatability of T measurement had an intraclass correlation coefficient (ICC) of 0.99 (P<0.001). We observed no structural cartilage damage and found no differences in T between children with (n=7) and without (n=6) inflamed knees (37.8 ms vs. 31.7 ms, P=0.20). However, we observed a moderate correlation between T values and the juvenile arthritis MRI synovitis score (r=0.59, P=0.04).
This pilot study suggests that T is a feasible and repeatable quantitative imaging technique in children. T values were associated with the juvenile arthritis MRI synovitis score.
儿童幼年特发性关节炎（JIA）持续存在的关节炎可导致软骨损伤。
研究 T 用于评估 JIA 膝关节软骨的可行性和可重复性，并描述 T 值，以及研究 T 值与疾病活动的常规 MRI 评分之间的相关性。
13 名患有 JIA 或疑似 JIA 的儿童接受了 3 特斯拉（T）膝关节 MRI 检查，包括常规序列和 T 序列。对 T 图像进行膝关节软骨分割。我们使用组内相关系数来研究 5 名儿童中的子集的分割可重复性。我们使用青少年关节炎 MRI 评分系统来区分炎症性和非炎症性膝关节。 Mann-Whitney U 和 Spearman 相关分析比较了 MRI 上有和无关节炎儿童的 T 值，并将 T 值与青少年关节炎 MRI 评分相关联。
所有儿童均成功完成 MRI 检查。没有因图像质量差而排除任何图像。 T 值测量的重复性具有组内相关系数（ICC）为 0.99（P<0.001）。我们没有观察到结构性软骨损伤，并且在有炎症（n=7）和无炎症（n=6）膝关节的儿童之间观察到 T 值没有差异（37.8 ms 与 31.7 ms，P=0.20）。但是，我们观察到 T 值与青少年关节炎 MRI 滑膜炎评分之间存在中度相关性（r=0.59，P=0.04）。
这项初步研究表明，T 是一种在儿童中可行且可重复的定量成像技术。 T 值与青少年关节炎 MRI 滑膜炎评分相关。
