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小脑功能解剖:基于人类 fMRI 证据的教学总结。

Cerebellar Functional Anatomy: a Didactic Summary Based on Human fMRI Evidence.

机构信息

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St., Boston, MA, USA.

Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology, 43 Vassar St., Cambridge, MA, USA.

出版信息

Cerebellum. 2020 Feb;19(1):1-5. doi: 10.1007/s12311-019-01083-9.

Abstract

The cerebellum is relevant for virtually all aspects of behavior in health and disease. Cerebellar findings are common across all kinds of neuroimaging studies of brain function and dysfunction. A large and expanding body of literature mapping motor and non-motor functions in the healthy human cerebellar cortex using fMRI has served as a tool for interpreting these findings. For example, results of cerebellar atrophy in Alzheimer's disease in caudal aspects of Crus I/II and medial lobule IX can be interpreted by consulting a large number of task, resting-state, and gradient-based reports that describe the functional characteristics of these specific aspects of the cerebellar cortex. Here, we provide a concise summary that outlines organizational principles observed consistently across these studies of normal cerebellar organization. This basic framework may be useful for investigators performing or reading experiments that require a functional interpretation of human cerebellar topography.

摘要

小脑与健康和疾病状态下的几乎所有行为方面都有关联。在各种脑功能和功能障碍的神经影像学研究中,都能发现小脑的表现。大量使用 fMRI 映射健康人类小脑皮层运动和非运动功能的文献,为解释这些发现提供了工具。例如,在 Crus I/II 和内侧小叶 IX 的尾部,可以通过参考大量描述小脑皮层这些特定区域的功能特征的任务、静息状态和基于梯度的报告,来解释阿尔茨海默病中小脑萎缩的结果。在这里,我们提供了一个简洁的总结,概述了在这些正常小脑组织研究中一致观察到的组织原则。这个基本框架对于进行或阅读需要对人类小脑拓扑进行功能解释的实验的研究人员可能很有用。

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