Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Faculdade de Ciências Básicas e da Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil.
Post-Graduation Program in Biomedical Engineering, Universidade Brasil, São Paulo, Brazil.
J Biophotonics. 2020 Mar;13(3):e201960140. doi: 10.1002/jbio.201960140. Epub 2020 Jan 7.
Photobiomodulation therapy (PBMT) in the infrared spectrum exerts positive effects on glucose metabolism, but the use of PBMT at the red spectrum has not been assessed. Male Swiss albino mice were divided into low-fat control and high-fat diet (HFD) for 12 weeks and were treated with red (630 nm) PBMT or no treatment (Sham) during weeks 9 to 12. PBMT was delivered at 31.19 J/cm , 60 J total dose per day for 20 days. In HFD-fed mice, PBMT improved glucose tolerance, insulin resistance and fasting hyperinsulinemia. PBMT also reduced adiposity and inflammatory infiltrate in adipose tissue. Phosphorylation of Akt in epididymal adipose tissue and rectus femoralis muscle was improved by PBMT. In epididymal fat PBMT reversed the reduced phosphorylation of AS160 and the reduced Glut4 content. In addition, PBMT reversed the alterations caused by HFD in rectus femoralis muscle on proteins involved in mitochondrial dynamics and β-oxidation. In conclusion, PBMT at red spectrum improved insulin resistance and glucose metabolism in HFD-fed mice.
光生物调节疗法（PBMT）在红外光谱下对葡萄糖代谢有积极影响，但红色光谱下的 PBMT 的应用尚未得到评估。雄性瑞士白化小鼠被分为低脂对照组和高脂肪饮食（HFD）12 周，并在第 9 至 12 周接受红色（630nm）PBMT 或无治疗（Sham）治疗。每天 31.19J/cm ，60J 总剂量，共 20 天。在 HFD 喂养的小鼠中，PBMT 改善了葡萄糖耐量、胰岛素抵抗和空腹高胰岛素血症。PBMT 还减少了脂肪组织中的脂肪堆积和炎症浸润。PBMT 改善了附睾脂肪组织和股直肌中 Akt 的磷酸化。在附睾脂肪中，PBMT 逆转了 AS160 磷酸化减少和 Glut4 含量减少。此外，PBMT 逆转了 HFD 对股直肌中线粒体动力学和β氧化相关蛋白的改变。综上所述，红色光谱下的 PBMT 改善了 HFD 喂养小鼠的胰岛素抵抗和葡萄糖代谢。
