Department of Radiology, Mayo Clinic, United States.
Thoracic Disease Research Unit, Mayo Clinic, United States.
J Biomech. 2020 Jan 2;98:109468. doi: 10.1016/j.jbiomech.2019.109468. Epub 2019 Oct 31.
Idiopathic pulmonary fibrosis is a progressively fatal disease with limited treatments. The bleomycin mouse model is often used to simulate the disease process in laboratory studies. The aim of this study was to develop an ex vivo technique for assessing mice lung injury using lung ultrasound surface wave elastography (LUSWE) in the bleomycin mouse model. The surface wave speeds were measured at three frequencies of 100, 200, and 300 Hz for mice lungs from control, mild, and severe groups. The results showed significant differences in the lung surface wave speeds, pulse oximetry, and compliance between control mice and mice with severe pulmonary fibrosis. LUSWE is an evolving technique for evaluating lung stiffness and may be useful for assessing pulmonary fibrosis in the bleomycin mouse model.
特发性肺纤维化是一种进行性致命疾病，治疗方法有限。博来霉素小鼠模型常用于实验室研究模拟疾病过程。本研究旨在开发一种使用肺超声表面波弹性成像（LUSWE）评估博来霉素小鼠模型中肺损伤的离体技术。在对照组、轻度组和重度组的小鼠肺中，分别测量了 100、200 和 300 Hz 三个频率的表面波速度。结果显示，对照组和重度肺纤维化小鼠的肺表面波速度、脉搏血氧饱和度和顺应性有显著差异。LUSWE 是一种评估肺硬度的新兴技术，可能对评估博来霉素小鼠模型中的肺纤维化有用。
