Department of Ultrasound, Pudong New Area Peoples' Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, China (mainland).
Department of General Surgery, Pudong New Area Peoples' Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, China (mainland).
Med Sci Monit. 2019 Nov 14;25:8571-8578. doi: 10.12659/MSM.918318.
BACKGROUND The aim of this study was to evaluate the association between prostate cancer (PCa) vascularity detected by superb microvascular imaging (SMI) and Gleason score in biopsy specimens. MATERIAL AND METHODS A total of 119 patients with suspected PCa before biopsy underwent gray-scale ultrasound (US), color Doppler ultrasound (CDUS), and SMI imaging between June 2018 and March 2019. Vascularity quantity was assessed by SMI and compared with that of CDUS. The vessel parameter was also compared with the Gleason score. The sensitivity of PCa was compared between transrectal ultrasound guided systematic biopsy (SB) and SMI-guided targeted biopsy (SMI-guided TB). RESULTS Pathology confirmed 74 of 119 patients had PCa. The microvascular quantity of PCa patients was significantly higher than that of non-malignant patients. SMI detected blood vessels in 97.3% (72/74) in the malignant group, while CDUS identified blood flow signals in 90.5% (67/74) of the PCa group. SMI visualized enriched microvascular in PCa of Gleason 8 (54.5%) and Gleason 9 (92.3%). There was a positive correlation between microvascular quantity detected by SMI and Gleason score, with a correlation coefficient of 0.373 (P<0.001). SMI-guided TB cores were significantly more likely than SB cores to detect PCa (OR=12.83, P<0.001). CONCLUSIONS SMI could be promising as a useful imaging technique in the detection and characterization of PCa. There was a positive correlation between microvascular quantity detected by SMI and Gleason score.
本研究旨在评估经超微血管成像（SMI）检测的前列腺癌（PCa）血管密度与活检标本中 Gleason 评分之间的关系。
2018 年 6 月至 2019 年 3 月期间，共有 119 例疑似 PCa 的患者在接受经直肠超声（TRUS）引导的系统活检（SB）之前接受了灰阶超声（US）、彩色多普勒超声（CDUS）和 SMI 成像检查。通过 SMI 评估血管数量，并与 CDUS 进行比较。还比较了血管参数与 Gleason 评分之间的关系。比较了经直肠超声引导系统活检（SB）和 SMI 引导靶向活检（SMI 引导 TB）对 PCa 的诊断敏感性。
病理证实 119 例患者中有 74 例患有 PCa。PCa 患者的微血管数量明显高于非恶性患者。SMI 在恶性组中检测到 97.3%（72/74）的血管，而 CDUS 在 PCa 组中检测到 90.5%（67/74）的血流信号。SMI 可视化了 Gleason 8（54.5%）和 Gleason 9（92.3%）的 PCa 丰富的微血管。SMI 检测到的微血管数量与 Gleason 评分呈正相关，相关系数为 0.373（P<0.001）。SMI 引导 TB 核心较 SB 核心更有可能检测到 PCa（OR=12.83，P<0.001）。
SMI 可能是一种有前途的检测和表征 PCa 的成像技术。SMI 检测到的微血管数量与 Gleason 评分呈正相关。
