我们如何验证旨在利用储备来改善衰老大脑的方法？
How do we validate approaches that aim to harness reserve to improve the aging brain?
机构信息
Pacific Health Research and Education Institute, Honolulu, HI, USA.
Department of Behavioral Sciences, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
出版信息
Neurobiol Aging. 2019 Nov;83:145-149. doi: 10.1016/j.neurobiolaging.2019.03.024.
An accurate assessment of the impact of reserve on cognitive functioning in older individuals with brain pathology requires careful measurement of each and an assessment of the extent to which each influences the other. Studies to integrate information about molecular biology, neuropathology, behavioral aspects of cognitive decline, and cognitive resilience will be of particular importance. In addition, more work is needed to improve our understanding of the effect of systemic factors on brain health and function. It seems likely that, even in later life, the brain's plasticity may allow for a positive response to stimulation. The ultimate goal of this research is to create a validated set of variables and interventions-and to understand the biology underlying them-that are useful not only in describing an individual's cognitive state but also in identifying promising paths for treatment and prevention of cognitive decline.
准确评估储备对脑病理老年个体认知功能的影响需要仔细测量每个储备，并评估每个储备对其他储备的影响程度。整合有关分子生物学、神经病理学、认知衰退的行为方面以及认知弹性的信息的研究将具有特别重要的意义。此外，还需要做更多的工作来增进我们对系统性因素对大脑健康和功能影响的理解。即使在晚年，大脑的可塑性似乎也可能允许对刺激产生积极的反应。这项研究的最终目标是创建一套经过验证的变量和干预措施，并了解其背后的生物学原理，这些不仅有助于描述个体的认知状态，还有助于确定有希望的治疗和预防认知衰退的途径。
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