I2FH, Institut d'Imagerie Fonctionelle Humaine, Montpellier University Hospital, Gui de Chauliac, 80 av. Augustin Fliche, 34295 Montpellier, France; Neuroradiology Department, Montpellier University Hospital, Gui de Chauliac, France.
Neurosurgery Department, Montpellier University Hospital, Gui de Chauliac, France; Team 'Plasticity of Central Nervous System, Stem Cells and Glial Tumors', INSERM U1051, Institute of Neuroscience Montpellier, France.
Neuroimage Clin. 2019;24:102010. doi: 10.1016/j.nicl.2019.102010. Epub 2019 Oct 24.
The dynamic connectome perspective states that brain functions arise from the functional integration of distributed and/or partly overlapping networks. Diffuse low-grade gliomas (DLGG) have a slow infiltrating character. Here we addressed whether and how anatomical disconnection following DLGG growth and resection might interfere with functional resting-state connectivity, specifically in relation to picture naming. Thirty-nine native French persons with a left DLGG were included. All underwent awake surgical resection of the tumor using direct brain electrostimulation to preserve critical eloquent regions. The anatomical disconnectivity risk following the DLGG volume and the resection, and the functional connectivity of resting-state fMRI images in relation to picture naming were evaluated prior to and three months after surgery. Resting-state connectivity patterns were compared with nineteen healthy controls. It was demonstrated that picture naming was strongly dependent on the semantic network that emerged from the integration and interaction of regions within multiple resting-state brain networks, in which their specific role could be explained in the light of the broader resting-state network they take part in. It emphasized the importance of a whole brain approach with specific clinical data input, during resting-state analysis in case of lesion. Adaptive plasticity was found in secondary regions, functionally connected to regions close to the tumor and/or cavity, marked by an increased connectivity of the right and left inferior parietal lobule with the left inferior temporal gyrus. In addition, an important role was identified for the superior parietal lobe, connected with the frontal operculum, suggesting functional compensation by means of attentional resources in order to name a picture via recruitment of the frontoparietal attention network.
动态连接组学观点认为，大脑功能源于分布式和/或部分重叠网络的功能整合。弥漫性低级别胶质瘤（DLGG）具有缓慢浸润的特征。在这里，我们探讨了 DLGG 生长和切除后解剖性断开是否以及如何干扰功能静息状态连接，特别是与图片命名的关系。39 名母语为法语的左侧 DLGG 患者被纳入研究。所有患者均采用清醒开颅手术，使用直接脑电刺激切除肿瘤，以保护关键的语言区域。在手术前和手术后三个月，评估了 DLGG 体积和切除后的解剖性断开风险，以及与图片命名相关的静息状态 fMRI 图像的功能连接。结果表明，图片命名强烈依赖于语义网络，该网络是由多个静息状态大脑网络内的区域的整合和相互作用产生的，其特定作用可以根据它们所参与的更广泛的静息状态网络来解释。这强调了在有病变的情况下，进行静息状态分析时，需要采用整体大脑方法，并结合特定的临床数据输入。适应性可塑性出现在与肿瘤和/或腔附近区域功能连接的次级区域中，表现为左右顶下小叶与左颞下回的连接增加。此外，顶叶上回与额盖之间的连接也具有重要作用，提示通过招募额顶注意网络来调用注意力资源进行图片命名，从而实现功能补偿。
