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器官捐献的改进:乘着国家悲剧的东风。

Improvements in organ donation: Riding the coattails of a national tragedy.

机构信息

Division of Digestive Health and Liver Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.

Emory University, Atlanta, GA, USA.

出版信息

Clin Transplant. 2020 Jan;34(1):e13755. doi: 10.1111/ctr.13755. Epub 2019 Dec 2.

Abstract

The US organ donation system has received attention from the highest levels of government. It has been debated whether increased donation is attributable solely to the opioid epidemic, or to broader performance improvements of the 58 OPOs. We evaluated Organ Procurement and Transplantation Network (OPTN) data of all deceased donors from 1/1/2009 to 12/31/2018. We hierarchically created four categories: (a) donor's mechanism of death coded as "drug intoxication" by the OPO; or donor coded as another mechanism of death but his/her history noted (b) intravenous drug use, (c) non-intravenous drug use (eg, snorting), or (d) no drug use. The first three categories were grouped as "drug-related." In 2018, there were 2700 more deceased donors than 2009. While the number of donors dying from a non-drug-related death decreased by 52, the number of drug-related deaths increased by 2752 (102% of increase from 2018 vs 2009). While there have been improvements in performance at some OPOs, based on these data it is indisputable that nationally the increased number of donors is almost wholly attributable to the drug epidemic, and reflects the byproduct of a national tragedy, rather than an improved system to be celebrated.

摘要

美国的器官捐赠系统已受到政府高层的关注。有人争论说,捐赠的增加是否仅仅归因于阿片类药物泛滥,还是归因于 58 个器官获取组织(OPO)更广泛的表现改善。我们评估了 2009 年 1 月 1 日至 2018 年 12 月 31 日期间所有已故捐赠者的器官获取和移植网络(OPTN)数据。我们分层创建了四个类别:(a)OPO 编码为“药物中毒”的捐赠者的死亡机制;或捐赠者被编码为其他死亡机制,但他/她的病史记录为(b)静脉内药物使用,(c)非静脉内药物使用(例如,鼻吸),或(d)无药物使用。前三个类别被归为“与药物相关”。2018 年,已故捐赠者比 2009 年多了 2700 人。虽然死于非药物相关死亡的捐赠者人数减少了 52 人,但与药物相关的死亡人数增加了 2752 人(与 2009 年相比,2018 年增加了 102%)。尽管一些 OPO 的表现有所改善,但根据这些数据,可以毫不含糊地说,全国范围内捐赠者人数的增加几乎完全归因于药物泛滥,这反映了国家悲剧的副产物,而不是值得庆祝的系统改进。

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