Division of Immunology, Rheumatology, and Allergy, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA.
Indoor Air. 2020 Mar;30(2):235-243. doi: 10.1111/ina.12625. Epub 2019 Dec 8.
Traffic-related airborne particles are associated with asthma morbidity. The aim of this study was to assess the impact of a high-efficiency particulate air (HEPA) filtration on the concentrations of traffic particles and the resultant effect on children with asthma. Forty-three children with asthma were enrolled in this double-blind, placebo-controlled crossover design. A HEPA air cleaner or a placebo "dummy" was placed in participants' homes for four weeks, interrupted by a one-month washout period, before crossing over to the other treatment arm for four weeks. Air sampling and health outcomes, including asthma control (ACQ) and quality of life (AQLQ) measures, were completed prior to and at the end of each treatment arm. Indoor concentrations of traffic particles were significantly reduced with the HEPA treatment but not with the "dummy" treatment. In participants with poorly controlled asthma and lower quality of life at baseline, ACQ and AQLQ scores were significantly improved (1.3 to 0.9, P = .003 and 4.9 to 5.5, P = .02, respectively) following the HEPA treatment. In this study, HEPA filtration is associated with improved clinical outcomes and quality of life measures in children with uncontrolled asthma.
交通相关的空气传播颗粒物与哮喘发病率有关。本研究旨在评估高效空气（HEPA）过滤对交通颗粒物浓度的影响，以及对哮喘儿童的影响。43 名哮喘患儿参与了这项双盲、安慰剂对照交叉设计的研究。在为期四周的试验中，参与者的家中放置了高效空气净化器或安慰剂“假”设备，然后中断一个月的洗脱期，再交叉到另一个治疗臂进行四周。在每次治疗前和结束时，完成空气采样和健康结果，包括哮喘控制（ACQ）和生活质量（AQLQ）的测量。HEPA 治疗可显著降低室内交通颗粒物浓度，但安慰剂治疗则无此效果。在基线时哮喘控制不佳和生活质量较低的参与者中，HEPA 治疗后 ACQ 和 AQLQ 评分显著改善（1.3 至 0.9，P=0.003 和 4.9 至 5.5，P=0.02）。在这项研究中，HEPA 过滤与未控制哮喘儿童的临床结局和生活质量测量的改善有关。
