• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

通过无玻片体内谐波产生显微镜对白种人和亚洲受试者的皮肤内在老化进行比较分析。

Comparative analysis of intrinsic skin aging between Caucasian and Asian subjects by slide-free in vivo harmonic generation microscopy.

作者信息

Lin Kuan-Hung, Liao Yi-Hua, Wei Ming-Liang, Sun Chi-Kuang

机构信息

Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

出版信息

J Biophotonics. 2020 Apr;13(4):e201960063. doi: 10.1002/jbio.201960063. Epub 2019 Dec 5.

DOI:10.1002/jbio.201960063
PMID:31747129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7894538/
Abstract

Phenotypical and functional differences in the intrinsic skin aging process of individuals between Caucasians and Asians have generated considerable interest in dermatology and cosmetic industry. Most of the studies focused on the stratum corneum, and in some other studies inter-individual differences overwhelms the racial difference. None of the studies comparatively analyzes the difference from the histopathological point of view. Here we report our harmonic generation microscopy study to analyze the difference of intrinsic aging between Caucasian and Asian skin from a histopathological point of view. As a result, the cellular and nuclear areas of basal cells in Caucasian subjects were found to increase at the same rate as the Asian subjects, ideal for scoring age. The maximum thickness of the viable epidermis, the dermal papilla (DP) volume per unit area and the depth of the DP zone in Caucasians were found to decrease at faster rates than those in Asians.

摘要

白种人和亚洲人在皮肤自然老化过程中的表型和功能差异引起了皮肤科和化妆品行业的广泛关注。大多数研究集中在角质层，在其他一些研究中，个体差异掩盖了种族差异。没有一项研究从组织病理学角度比较分析这种差异。在此，我们报告我们的谐波产生显微镜研究，从组织病理学角度分析白种人和亚洲人皮肤自然老化的差异。结果发现，白种人受试者基底细胞的细胞和核面积与亚洲受试者以相同速率增加，这对于年龄评分是理想的。发现白种人有活力表皮的最大厚度、单位面积真皮乳头（DP）体积和DP区深度的下降速度比亚洲人更快。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/d1509f875b44/JBIO-13-e201960063-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/ef964eccc4dc/JBIO-13-e201960063-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/ad0c4989e387/JBIO-13-e201960063-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/9a521dde2ea3/JBIO-13-e201960063-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/6b11b2c188ca/JBIO-13-e201960063-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/590c61b60679/JBIO-13-e201960063-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/bfb8f39e08d0/JBIO-13-e201960063-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/6b47bcffeb4b/JBIO-13-e201960063-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/d578da478026/JBIO-13-e201960063-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/60d22e37e09d/JBIO-13-e201960063-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/9a92e9fc32da/JBIO-13-e201960063-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/192458342896/JBIO-13-e201960063-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/31f7786aba80/JBIO-13-e201960063-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/6007a74d12fc/JBIO-13-e201960063-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/af77d65d9c0c/JBIO-13-e201960063-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/993184ed4f39/JBIO-13-e201960063-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/a730701274cb/JBIO-13-e201960063-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/5eee8f374b9a/JBIO-13-e201960063-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/54589977c75e/JBIO-13-e201960063-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/e764d7e10738/JBIO-13-e201960063-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/a5ef450fa489/JBIO-13-e201960063-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/d1509f875b44/JBIO-13-e201960063-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/ef964eccc4dc/JBIO-13-e201960063-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/ad0c4989e387/JBIO-13-e201960063-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/9a521dde2ea3/JBIO-13-e201960063-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/6b11b2c188ca/JBIO-13-e201960063-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/590c61b60679/JBIO-13-e201960063-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/bfb8f39e08d0/JBIO-13-e201960063-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/6b47bcffeb4b/JBIO-13-e201960063-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/d578da478026/JBIO-13-e201960063-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/60d22e37e09d/JBIO-13-e201960063-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/9a92e9fc32da/JBIO-13-e201960063-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/192458342896/JBIO-13-e201960063-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/31f7786aba80/JBIO-13-e201960063-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/6007a74d12fc/JBIO-13-e201960063-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/af77d65d9c0c/JBIO-13-e201960063-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/993184ed4f39/JBIO-13-e201960063-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/a730701274cb/JBIO-13-e201960063-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/5eee8f374b9a/JBIO-13-e201960063-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/54589977c75e/JBIO-13-e201960063-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/e764d7e10738/JBIO-13-e201960063-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/a5ef450fa489/JBIO-13-e201960063-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/7894538/d1509f875b44/JBIO-13-e201960063-g021.jpg

相似文献

1
Comparative analysis of intrinsic skin aging between Caucasian and Asian subjects by slide-free in vivo harmonic generation microscopy.通过无玻片体内谐波产生显微镜对白种人和亚洲受试者的皮肤内在老化进行比较分析。
J Biophotonics. 2020 Apr;13(4):e201960063. doi: 10.1002/jbio.201960063. Epub 2019 Dec 5.
2
Comparison of facial skin ageing in healthy Asian and Caucasian females quantified by in vivo line-field confocal optical coherence tomography 3D imaging.应用体视学共聚焦激光扫描显微镜 3D 成像技术定量比较亚洲健康女性与高加索健康女性的面部皮肤老化。
Skin Res Technol. 2024 Sep;30(9):e13643. doi: 10.1111/srt.13643.
3
Quantitative analysis of intrinsic skin aging in dermal papillae by in vivo harmonic generation microscopy.通过体内谐波发生显微镜对真皮乳头内皮肤自然老化进行定量分析。
Biomed Opt Express. 2014 Aug 28;5(9):3266-79. doi: 10.1364/BOE.5.003266. eCollection 2014 Sep 1.
4
Objective evaluation of the effects of intense pulsed light treatment on Asian skin by reflectance confocal microscopy analysis.通过反射式共聚焦显微镜分析客观评估强脉冲光治疗对亚洲皮肤的效果。
Lasers Med Sci. 2018 May;33(4):779-784. doi: 10.1007/s10103-017-2419-z. Epub 2017 Dec 18.
5
In vivo evaluation of the stratum corneum barrier function in blacks, Caucasians and Asians with two noninvasive methods.采用两种非侵入性方法对黑人、白人和亚洲人的角质层屏障功能进行体内评估。
Skin Pharmacol. 1993;6(3):200-7. doi: 10.1159/000211136.
6
The Caucasian and African skin types differ morphologically and functionally in their dermal component.高加索人种和非洲人种的皮肤类型在其真皮成分上存在形态和功能上的差异。
Exp Dermatol. 2009 Aug;18(8):704-11. doi: 10.1111/j.1600-0625.2009.00843.x. Epub 2009 Mar 12.
7
Determination of chronological aging parameters in epidermal keratinocytes by in vivo harmonic generation microscopy.通过体内谐波产生显微镜测定表皮角质形成细胞的自然衰老参数。
Biomed Opt Express. 2013 Jan 1;4(1):77-88. doi: 10.1364/BOE.4.000077. Epub 2012 Dec 13.
8
In vivo quantification of epidermis pigmentation and dermis papilla density with reflectance confocal microscopy: variations with age and skin phototype.利用反射共聚焦显微镜对表皮色素沉着和真皮乳头密度进行体内定量分析：年龄和皮肤光型的变化。
Exp Dermatol. 2012 Apr;21(4):281-6. doi: 10.1111/j.1600-0625.2012.01451.x.
9
Comparative study of the hydration of the stratum corneum between four ethnic groups: influence of age.四个种族群体角质层水合作用的比较研究：年龄的影响
Int J Dermatol. 2007 Oct;46 Suppl 1:11-4. doi: 10.1111/j.1365-4632.2007.03455.x.
10
Differences in bone mineral in young Asian and Caucasian Americans may reflect differences in bone size.年轻的亚裔美国人和高加索裔美国人在骨矿物质方面的差异可能反映出骨骼大小的差异。
J Bone Miner Res. 1996 Oct;11(10):1545-56. doi: 10.1002/jbmr.5650111023.

引用本文的文献

1
Patient Satisfaction Using Hybrid Cooperative Complexes of Hyaluronic Acid for Neck Laxity: A Survey of Asian Populations.使用透明质酸混合协同复合物治疗颈部松弛的患者满意度：亚洲人群调查
Plast Aesthet Nurs (Phila). 2025;45(3):163-172. doi: 10.1097/PSN.0000000000000609. Epub 2025 Jul 9.
2
Comparison of facial skin ageing in healthy Asian and Caucasian females quantified by in vivo line-field confocal optical coherence tomography 3D imaging.应用体视学共聚焦激光扫描显微镜 3D 成像技术定量比较亚洲健康女性与高加索健康女性的面部皮肤老化。
Skin Res Technol. 2024 Sep;30(9):e13643. doi: 10.1111/srt.13643.
3
Discontinuity third harmonic generation microscopy for label-free imaging and quantification of intraepidermal nerve fibers.

本文引用的文献

1
Quantitative analysis of intrinsic skin aging in dermal papillae by in vivo harmonic generation microscopy.通过体内谐波发生显微镜对真皮乳头内皮肤自然老化进行定量分析。
Biomed Opt Express. 2014 Aug 28;5(9):3266-79. doi: 10.1364/BOE.5.003266. eCollection 2014 Sep 1.
2
Automatic cell segmentation and nuclear-to-cytoplasmic ratio analysis for third harmonic generated microscopy medical images.用于三次谐波产生显微镜医学图像的自动细胞分割和核质比分析。
IEEE Trans Biomed Circuits Syst. 2013 Apr;7(2):158-68. doi: 10.1109/TBCAS.2013.2253463.
3
Determination of chronological aging parameters in epidermal keratinocytes by in vivo harmonic generation microscopy.
用于无标记成像和定量检测表皮内神经纤维的不连续三次谐波产生显微镜。
Cell Rep Methods. 2024 Mar 25;4(3):100735. doi: 10.1016/j.crmeth.2024.100735. Epub 2024 Mar 18.
4
Quantitative morphometric analysis of intrinsic and extrinsic skin ageing in individuals with Fitzpatrick skin types II-III.定量形态计量分析 II-III 型皮肤 Fitzpatrick 皮肤个体的内在和外在皮肤老化。
Exp Dermatol. 2023 May;32(5):620-631. doi: 10.1111/exd.14754. Epub 2023 Feb 3.
5
In vivo harmonic generation microscopy for monitoring the height of basal keratinocytes in solar lentigines after laser depigmentation treatment.用于监测激光色素沉着治疗后日光性雀斑中基底角质形成细胞高度的体内谐波产生显微镜检查。
Biomed Opt Express. 2021 Sep 9;12(10):6129-6142. doi: 10.1364/BOE.434789. eCollection 2021 Oct 1.
6
Investigating the optical clearing effects of 50% glycerol in ex vivo human skin by harmonic generation microscopy.利用谐波产生显微镜研究 50%甘油对离体人皮肤的光学透明化效果。
Sci Rep. 2021 Jan 11;11(1):329. doi: 10.1038/s41598-020-77889-z.
7
The Human Epidermal Basement Membrane: A Shaped and Cell Instructive Platform That Aging Slowly Alters.人类表皮基底膜：一种形态和细胞指令性平台，随年龄缓慢改变。
Biomolecules. 2020 Nov 27;10(12):1607. doi: 10.3390/biom10121607.
8
Slide-free clinical imaging of melanin with absolute quantities using label-free third-harmonic-generation enhancement-ratio microscopy.使用无标记三次谐波产生增强率显微镜对黑色素进行无载玻片临床成像并测定绝对含量。
Biomed Opt Express. 2020 May 11;11(6):3009-3024. doi: 10.1364/BOE.391451. eCollection 2020 Jun 1.
通过体内谐波产生显微镜测定表皮角质形成细胞的自然衰老参数。
Biomed Opt Express. 2013 Jan 1;4(1):77-88. doi: 10.1364/BOE.4.000077. Epub 2012 Dec 13.
4
In vivo observation of age-related structural changes of dermal collagen in human facial skin using collagen-sensitive second harmonic generation microscope equipped with 1250-nm mode-locked Cr:Forsterite laser.采用配备 1250nm 锁模 Cr:Forsterite 激光的胶原敏感二次谐波显微镜观察人面部皮肤中与年龄相关的真皮胶原结构变化。
J Biomed Opt. 2013 Mar;18(3):31108. doi: 10.1117/1.JBO.18.3.031108.
5
Optical harmonic generation from animal tissues by the use of picosecond and femtosecond laser pulses.利用皮秒和飞秒激光脉冲从动物组织中产生光学谐波。
Appl Opt. 1996 Dec 1;35(34):6810-3. doi: 10.1364/AO.35.006810.
6
In vivo measurement of the human epidermal thickness in different localizations by multiphoton laser tomography.应用多光子激光断层成像术测量不同部位人体表皮厚度。
Skin Res Technol. 2010 Aug;16(3):259-64. doi: 10.1111/j.1600-0846.2010.00437.x.
7
In vivo harmonic generation biopsy of human skin.人体皮肤的体内谐波产生活组织检查。
J Biomed Opt. 2009 Nov-Dec;14(6):060505. doi: 10.1117/1.3269676.
8
Effect of aging on cellular mechanotransduction.衰老对细胞机械转导的影响。
Ageing Res Rev. 2011 Jan;10(1):1-15. doi: 10.1016/j.arr.2009.11.002. Epub 2009 Nov 20.
9
In vivo optical biopsy of hamster oral cavity with epi-third-harmonic-generation microscopy.利用落射式三次谐波产生显微镜对仓鼠口腔进行体内光学活检。
Opt Express. 2006 Jun 26;14(13):6178-87. doi: 10.1364/oe.14.006178.
10
Assessing the risk of skin damage due to femtosecond laser irradiation.评估飞秒激光照射导致皮肤损伤的风险。
J Biophotonics. 2008 Dec;1(6):470-7. doi: 10.1002/jbio.200810050.