Afrasiabi Shima, Pourhajibagher Maryam, Bahador Abbas
Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
J Lasers Med Sci. 2019 Summer;10(3):241-250. doi: 10.15171/jlms.2019.39. Epub 2019 Jul 6.
Periodontitis is one of the most common inflammatory diseases of the periodontium, which results in the inflammatory destruction of supporting structures around teeth and is closely associated with the development of systemic disease. Due to a wide variety of antibiotic resistance periodontopathic bacteria, photodynamic therapy (PDT) is a non-invasive adjunctive therapeutic modality that is capable of destroying the whole range of microbes. Metformin (Metf) is an antidiabetic drug, and recent studies suggest that cancer patients who receive Metf and are exposed to radiotherapy and chemotherapy show better outcomes. Our surveys in this review introduce Metf as a potent stimulus in increasing the efficacy of PDT in the induction of destruction in microbial cells.
牙周炎是最常见的牙周组织炎症性疾病之一，它会导致牙齿周围支持结构的炎症性破坏，并且与全身性疾病的发展密切相关。由于多种牙周病原菌具有抗生素耐药性，光动力疗法（PDT）是一种能够消灭所有微生物的非侵入性辅助治疗方式。二甲双胍（Metf）是一种抗糖尿病药物，最近的研究表明，接受Metf治疗并接受放疗和化疗的癌症患者预后更好。我们在本综述中的调查表明，Metf是提高PDT诱导微生物细胞破坏效果的一种有效刺激物。
