Afrasiabi Shima, Partoazar Alireza, Chiniforush Nasim, Goudarzi Ramin
Laser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran 1441987566, Iran.
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran 1441987566, Iran.
Pharmaceuticals (Basel). 2022 Jun 20;15(6):767. doi: 10.3390/ph15060767.
Oral health problems and the emergence of antimicrobial resistance among pathogenic bacterial strains have become major global challenges and are essential elements that negatively affect general well-being. Antimicrobial photodynamic therapy (APDT) is based on a light source and oxygen that activates a nontoxic photosensitizer, resulting in microbial destruction. Synthetic and natural products can be used to help the APDT against oral microorganisms. The undesirable consequences of conventional photosensitizers, including toxicity, and cost encourage researchers to explore new promising photosensitizers based on natural compounds such as curcumin, , chlorophyllin, phycocyanin, 5-aminolevulinic acid, and riboflavin. In this review, we summarize in vitro studies describing the potential use of APDT therapy conjugated with some natural products against selected microorganisms that are considered to be responsible for oral infections.
口腔健康问题以及致病细菌菌株中抗菌药物耐药性的出现已成为全球主要挑战，并且是对总体健康产生负面影响的重要因素。抗菌光动力疗法（APDT）基于光源和氧气，可激活无毒的光敏剂，从而导致微生物被破坏。合成产品和天然产品可用于辅助APDT对抗口腔微生物。传统光敏剂的不良后果，包括毒性和成本，促使研究人员探索基于姜黄素、叶绿酸、藻蓝蛋白、5-氨基乙酰丙酸和核黄素等天然化合物的新型有前景的光敏剂。在本综述中，我们总结了体外研究，这些研究描述了APDT疗法与某些天然产品结合对被认为是导致口腔感染的特定微生物的潜在用途。
