Clinic of Trauma, Hand and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Int J Mol Sci. 2019 Nov 19;20(22):5805. doi: 10.3390/ijms20225805.
Bone regeneration represents a complex process, of which basic biologic principles have been evolutionarily conserved over a broad range of different species. Bone represents one of few tissues that can heal without forming a fibrous scar and, as such, resembles a unique form of tissue regeneration. Despite a tremendous improvement in surgical techniques in the past decades, impaired bone regeneration including non-unions still affect a significant number of patients with fractures. As impaired bone regeneration is associated with high socio-economic implications, it is an essential clinical need to gain a full understanding of the pathophysiology and identify novel treatment approaches. This review focuses on the clinical implications of impaired bone regeneration, including currently available treatment options. Moreover, recent advances in the understanding of fracture healing are discussed, which have resulted in the identification and development of novel therapeutic approaches for affected patients.
骨再生是一个复杂的过程，其基本生物学原理在广泛的不同物种中得到了进化上的保守。骨是少数几种可以在不形成纤维瘢痕的情况下愈合的组织之一，因此类似于一种独特的组织再生形式。尽管过去几十年手术技术有了巨大的进步，但包括骨折不愈合在内的骨再生受损仍然影响着大量骨折患者。由于骨再生受损与高社会经济影响相关，因此充分了解其病理生理学并确定新的治疗方法是至关重要的临床需求。本综述重点讨论了骨再生受损的临床意义，包括目前可用的治疗选择。此外，还讨论了骨折愈合理解方面的最新进展，这些进展导致了针对受影响患者的新型治疗方法的识别和开发。
