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丁香 DC 根提取物中原花青素的抗菌和抗炎活性研究。

Investigation of Antibacterial and Antiinflammatory Activities of Proanthocyanidins from DC Root Extract.

机构信息

Medical Academy, Lithuanian University of Health Sciences, Sukileliu Ave. 13, LT-50162 Kaunas, Lithuania.

Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, LV1006 Riga, Latvia.

出版信息

Nutrients. 2019 Nov 19;11(11):2829. doi: 10.3390/nu11112829.

DOI:10.3390/nu11112829
PMID:31752295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6893413/
Abstract

The study explores antibacterial, antiinflammatory and cytoprotective capacity of DC root extract (PSRE) and proanthocyanidin fraction from PSRE (PACN) under conditions characteristic for periodontal disease. Following previous finding that PACN exerts stronger suppression of compared to the effect on commensal , the current work continues antibacterial investigation on , , and PSRE and PACN are also studied for their ability to prevent gingival fibroblast cell death in the presence of bacteria or bacterial lipopolysaccharide (LPS), to block LPS- or LPS + IFNγ-induced release of inflammatory mediators, gene expression and surface antigen presentation. Both PSRE and PACN were more efficient in suppressing and compared to , prevented - and LPS-induced death of fibroblasts, decreased LPS-induced release of interleukin-8 and prostaglandin E2 from fibroblasts and IL-6 from leukocytes, blocked expression of IL-1β, iNOS, and surface presentation of CD80 and CD86 in LPS + IFNγ-treated macrophages, and IL-1β and COX-2 expression in LPS-treated leukocytes. None of the investigated substances affected either the level of secretion or expression of TNFα. In conclusion, PSRE, and especially PACN, possess strong antibacterial, antiinflammatory and gingival tissue protecting properties under periodontitis-mimicking conditions and are suggestable candidates for treatment of the disease.

摘要

该研究在牙周病特征条件下探索了 DC 根提取物（PSRE）和 PSRE 中原花青素（PACN）的抗菌、抗炎和细胞保护能力。先前发现 PACN 对 的抑制作用强于对共生 的作用，目前的工作继续对 、 、 和 PSRE 进行抗菌研究，并研究它们在存在细菌或细菌脂多糖（LPS）的情况下防止牙龈成纤维细胞死亡、阻止 LPS 或 LPS + IFNγ 诱导的炎症介质释放、基因表达和表面抗原呈递的能力。与 相比，PSRE 和 PACN 更有效地抑制 ，防止 - 和 LPS 诱导的成纤维细胞死亡，减少 LPS 诱导的成纤维细胞中白细胞介素-8 和前列腺素 E2 以及白细胞中的白细胞介素-6 的释放，阻断 LPS + IFNγ 处理的巨噬细胞中 IL-1β、iNOS 和 CD80 和 CD86 的表面呈递以及 LPS 处理的白细胞中 IL-1β 和 COX-2 的表达。所研究的物质均不影响 TNFα 的分泌或表达水平。总之，PSRE，尤其是 PACN，在模拟牙周炎的条件下具有强大的抗菌、抗炎和牙龈组织保护特性，是治疗该疾病的候选药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7817/6893413/9a44dfcdc643/nutrients-11-02829-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7817/6893413/030404aedda9/nutrients-11-02829-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7817/6893413/b897faaa8798/nutrients-11-02829-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7817/6893413/f20cce19ddaa/nutrients-11-02829-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7817/6893413/418549e4170e/nutrients-11-02829-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7817/6893413/3cc5bf05700c/nutrients-11-02829-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7817/6893413/9bbc7cadb7fe/nutrients-11-02829-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7817/6893413/9a44dfcdc643/nutrients-11-02829-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7817/6893413/030404aedda9/nutrients-11-02829-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7817/6893413/b897faaa8798/nutrients-11-02829-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7817/6893413/f20cce19ddaa/nutrients-11-02829-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7817/6893413/418549e4170e/nutrients-11-02829-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7817/6893413/3cc5bf05700c/nutrients-11-02829-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7817/6893413/9bbc7cadb7fe/nutrients-11-02829-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7817/6893413/9a44dfcdc643/nutrients-11-02829-g007.jpg

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