Sunnybrook Research Institute, Toronto, Ontario, Canada.
Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, 2075 Bayview Ave. D7 04, Toronto, Ontario, M4N 3M5, Canada.
Stem Cell Res Ther. 2019 Nov 21;10(1):337. doi: 10.1186/s13287-019-1465-9.
The most important determinant of survival post-burn injury is wound healing. For decades, allogeneic mesenchymal stem cells (MSCs) have been suggested as a potential treatment for severe burn injuries. This report describes a patient with a severe burn injury whose wounds did not heal with over 18 months of conventional burn care. When treated with allogeneic MSCs, wound healing accelerated with no adverse treatment complications. Wound sites showed no evidence of keloids or hypertrophic formation during a 6-year follow-up period. This therapeutic use of allogeneic MSCs for large non-healing burn wounds was deemed safe and effective and has great treatment potential.
烧伤后存活的最重要决定因素是伤口愈合。几十年来，同种异体间充质干细胞（MSCs）一直被认为是严重烧伤的一种潜在治疗方法。本报告描述了一名严重烧伤患者，其伤口在经过 18 多个月的常规烧伤治疗后仍未愈合。用同种异体 MSCs 治疗后，伤口愈合加速，没有出现治疗并发症。在 6 年的随访期间，伤口部位没有出现瘢痕瘤或增生形成的迹象。这种同种异体 MSCs 治疗大面积非愈合性烧伤创面的方法被认为是安全有效的，具有很大的治疗潜力。
