Office of Disease Prevention, NIH, Rockville, Maryland.
National Cancer Institute, NIH, Rockville, Maryland.
Am J Prev Med. 2019 Dec;57(6):818-825. doi: 10.1016/j.amepre.2019.07.023.
Poor diet and inadequate physical activity are common contributors to preventable death in the U.S. This paper provides a summary of the NIH-sponsored research on disease prevention that underlies public health and clinical recommendations to improve diet and physical activity.
A representative sample (n=11,082) of research grants and cooperative agreements (research projects) representing the NIH prevention research portfolio between 2012 and 2017 were hand coded by trained analysts in 2017-2018. This manuscript describes the rationale(s), exposure(s), outcome(s), population(s), and study design(s) in prevention research focused on diet and physical activity and compares this research to identified research gaps in the field.
A relatively stable 7.8% (95% CI=7.0%, 8.8%) and 5.0% (95% CI=4.4%, 5.7%) of the NIH prevention research projects were focused on diet and physical activity, respectively, during 2012-2017. These projects often explored diet and physical activity together in the context of obesity, included observational studies, and focused on a general adult population. Few of these projects focused on development of improved assessment methods. Approximately 50% of these studies were related to research gaps identified by the 2015 Dietary or 2018 Physical Activity Guidelines Advisory Committee Scientific Reports.
Opportunities exist for more engagement by NIH and scientific investigators in diet- and physical activity-focused prevention research, particularly around assessment and known research gaps.
不良的饮食和缺乏身体活动是导致美国可预防死亡的常见因素。本文概述了美国国立卫生研究院(NIH)赞助的疾病预防研究,这些研究为改善饮食和身体活动的公共卫生和临床建议提供了依据。
通过受过培训的分析师,在 2017-2018 年对 2012 年至 2017 年间代表 NIH 预防研究组合的具有代表性的研究赠款和合作协议(研究项目)样本(n=11,082)进行手工编码。本文描述了以饮食和身体活动为重点的预防研究的基本原理、暴露、结果、人群和研究设计,并将该研究与该领域已确定的研究差距进行了比较。
在 2012-2017 年期间,NIH 预防研究项目中,约有 7.8%(95%置信区间=7.0%,8.8%)和 5.0%(95%置信区间=4.4%,5.7%)的项目分别专注于饮食和身体活动。这些项目通常在肥胖背景下探讨饮食和身体活动,包括观察性研究,并关注一般成年人群。这些项目中很少有项目专注于开发改进的评估方法。这些研究中约有 50%与 2015 年饮食或 2018 年身体活动指南咨询委员会科学报告确定的研究差距有关。
NIH 和科学研究人员有机会更多地参与以饮食和身体活动为重点的预防研究,特别是在评估和已知研究差距方面。