Ceit, Manuel Lardizábal 15, 20018, Donostia-San Sebastián, Spain; Universidad de Navarra, Tecnun, Manuel Lardizábal 13, 20018, Donostia-San Sebastián, Spain.
Ceit, Manuel Lardizábal 15, 20018, Donostia-San Sebastián, Spain; Universidad de Navarra, Tecnun, Manuel Lardizábal 13, 20018, Donostia-San Sebastián, Spain; Department of Biology, Regis University, Denver, CO, 80221, USA.
Mater Sci Eng C Mater Biol Appl. 2020 Jan;106:110261. doi: 10.1016/j.msec.2019.110261. Epub 2019 Oct 14.
Limitations in effectiveness and the invasive nature of current cancer treatment options emphasize the need for further clinical advancements. Among other approaches, targeted hyperthermia is as a new strategy aimed at targeting cancerous cells to improve the efficacy of radiotherapy or cytotoxic drugs. However, the testing of magnetic vehicles has mainly focused on the use of nanoparticles. In this work, FeBSiC glass-coated amorphous magnetic microwires were assessed for the first time as magnetic vehicles with high potential for the localized heating of osteosarcoma cells by means of an AC magnetic field. The results from the in vitro assays performed inside a microfluidic device demonstrated the ability of these magnetic microwires to induce malignant cell death. Exposing the system to different magnetic fields for less than 1 h provoked a reduction up to 89% of the osteosarcoma cell population, whereas healthy myoblastoma cells remained nearly unaffected. The proposed technology demonstrates in vitro the effectiveness of these microwires as vehicles for targeted magnetic hyperthermia.
目前癌症治疗方案的疗效有限且具有侵袭性，这强调了需要进一步的临床进展。除其他方法外，靶向热疗是一种新策略，旨在针对癌细胞以提高放疗或细胞毒性药物的疗效。然而，磁性载体的测试主要集中在纳米颗粒的使用上。在这项工作中，首次评估了 FeBSiC 玻璃涂层非晶态磁性微丝作为磁性载体，通过交流磁场将其用于局部加热骨肉瘤细胞，具有很大的潜力。在微流控装置内进行的体外试验结果表明，这些磁性微丝能够诱导恶性细胞死亡。将系统暴露于磁场中不到 1 小时，可将骨肉瘤细胞群减少多达 89%，而健康的成肌细胞瘤细胞几乎不受影响。所提出的技术在体外证明了这些微丝作为靶向磁热疗载体的有效性。
