Busuioc Cristina, Olaret Elena, Stancu Izabela-Cristina, Nicoara Adrian-Ionut, Jinga Sorin-Ion
Science and Engineering of Oxide Materials and Nanomaterials Department, University Politehnica of Bucharest, 1-7 Polizu Street, District 1, RO-011061 Bucharest, Romania.
Advanced Polymer Materials Group, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu Street, District 1, RO-011061 Bucharest, Romania.
Nanomaterials (Basel). 2020 Apr 16;10(4):772. doi: 10.3390/nano10040772.
The current work focuses on the development of mineral scaffolds with complex composition and controlled morphology by using a polymeric template in the form of nonwoven fibre webs fabricated through electrospinning. By a cross-linking process, gelatine fibres stable in aqueous solutions were achieved, these being further subjected to a loading step with two types of mineral phases: calcium phosphates deposited by chemical reaction and barium titanate nanoparticles as decoration on the previously achieved structures. Thus, hybrid materials were obtained and subsequently processed in terms of freeze-drying and heat treating with the purpose of burning the template and consolidating the mineral part as potential bone implants with improved biological response by external stimulation. The results confirmed the tunable morphology, as well as the considerable applicability of both as-prepared and final samples for the development of medical devices, which encourages the continuation of research in the direction of assessing the synergistic contribution of barium titanate domains polarisation/magnetisation by external applied fields.
当前的工作重点是通过使用以静电纺丝制备的非织造纤维网形式的聚合物模板，开发具有复杂组成和可控形态的矿物支架。通过交联过程，获得了在水溶液中稳定的明胶纤维，这些纤维进一步经历了两种矿物相的负载步骤：通过化学反应沉积的磷酸钙和作为装饰的钛酸钡纳米颗粒沉积在先前获得的结构上。因此，获得了杂化材料，随后对其进行冷冻干燥和热处理，目的是烧掉模板并巩固矿物部分，使其成为具有通过外部刺激改善生物反应的潜在骨植入物。结果证实了形态的可调性，以及所制备的样品和最终样品在医疗设备开发中的相当大的适用性，这鼓励继续朝着评估外部施加场对钛酸钡域极化/磁化的协同贡献方向进行研究。
