聚羟基脂肪酸酯（PHA）：在骨支架中的作用。
Poly hydroxyalkanoates (PHA): Role in bone scaffolds.
作者信息
Dwivedi Ruby, Pandey Rahul, Kumar Sumit, Mehrotra Divya
机构信息
Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, KGMU, Lucknow, UP, India.
DHR-MRU, Faculty of Dental Sciences, KGMU, Lucknow, UP, India.
出版信息
J Oral Biol Craniofac Res. 2020 Jan-Mar;10(1):389-392. doi: 10.1016/j.jobcr.2019.10.004. Epub 2019 Nov 5.
Abstract
Polyhydroxyalkanoates (PHA) are prokaryotic macromolecules accumulated within the cytoplasm as granules. Due to their suitable mechanical properties, biocompatibility, degradation time, ability to be blended, surface modified, and form copolymers, it is widely used in medical devices and as scaffolds in bone tissue engineering. This review describes in brief the production and extraction sources, physico-chemical characteristic, mechanical properties, degradation rate and applications of various PHAs and its copolymers with special emphasis to its role as scaffolds in bone tissue engineering.
摘要
聚羟基脂肪酸酯（PHA）是原核生物的大分子，作为颗粒在细胞质中积累。由于其具有合适的机械性能、生物相容性、降解时间、可共混性、表面可改性以及形成共聚物的能力，它被广泛应用于医疗器械以及骨组织工程中的支架。本综述简要描述了各种PHA及其共聚物的生产和提取来源、物理化学特性、机械性能、降解速率和应用，特别强调了其在骨组织工程中作为支架的作用。
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