Centre International de Recherche-Développement sur l'Elevage en zones Subhumides (CIRDES), Unité de recherches sur les maladies à vecteurs et biodiversité, 01 BP 454 Bobo-Dioulasso 01, Burkina Faso - Université Nazi Boni, Bobo-Dioulasso, 01 BP 1091 Bobo-Dioulasso, Burkina Faso.
Programme National de Lutte contre la Trypanosomose Humaine Africaine, BP 851, Conakry, Guinée.
Parasite. 2019;26:68. doi: 10.1051/parasite/2019066. Epub 2019 Nov 22.
The World Health Organization (WHO) has set the goal of gambiense-Human African trypanosomiasis (HAT) elimination as a public health problem for 2020 and interruption of transmission in humans for 2030. In this context, it is crucial to monitor progress towards these targets using accurate tools to assess the level of transmission in a given area. The aim of this study was to investigate the relevance of the immune trypanolysis test (TL) as a population-based bioassay to evaluate Trypanosoma brucei gambiense transmission in various epidemiological contexts. Significant correlations were observed between HAT endemicity levels and the percentage of TL-positive individuals in the population. TL therefore appears to be a suitable population-based biomarker of the intensity of transmission. In addition to being used as a tool to assess the HAT status at an individual level, assessing the proportion of TL positive individuals in the population appears as a promising and easy alternative to monitor the elimination of gambiense HAT in a given area.
世界卫生组织（WHO）已经设定了在 2020 年消除冈比亚锥虫病（HAT）这一公共卫生问题，并在 2030 年阻断人类传播的目标。在这种情况下，使用准确的工具监测实现这些目标的进展情况，以评估特定地区的传播水平至关重要。本研究旨在探讨免疫溶解试验（TL）作为一种基于人群的生物测定法，在不同流行病学背景下评估冈比亚锥虫传播的相关性。在人群中，观察到 HAT 流行程度与 TL 阳性个体的百分比之间存在显著相关性。因此，TL 似乎是一种适合基于人群的传播强度的生物标志物。除了作为一种在个体水平上评估 HAT 状况的工具外，评估人群中 TL 阳性个体的比例似乎是一种很有前途且简单的替代方法，可用于监测特定地区冈比亚锥虫病的消除情况。
