深入了解牙干细胞分泌组对神经再生的影响：迈向无细胞治疗
Insights into the Effects of the Dental Stem Cell Secretome on Nerve Regeneration: Towards Cell-Free Treatment.
作者信息
Man Rohaina Che, Sulaiman Nadiah, Idrus Ruszymah Bt Hj, Ariffin Shahrul Hisham Zainal, Wahab Rohaya Megat Abdul, Yazid Muhammad Dain
机构信息
Tissue Engineering Centre, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia.
Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia.
出版信息
Stem Cells Int. 2019 Oct 24;2019:4596150. doi: 10.1155/2019/4596150. eCollection 2019.
Cell-free treatment is emerging as an alternative to cell delivery to promote endogenous regeneration using cell-derived factors. The purpose of this article was to systematically review studies of the effects of the dental stem cell secretome on nerve regeneration. PubMed and Scopus databases were used where searched and related studies were selected. The primary search identified 36 articles with the utilized keywords; however, only 13 articles met the defined inclusion criteria. Eight out of thirteen articles included and studies. We classified the dental stem cell-derived secretome with its nerve regeneration potential. All studies demonstrated that dental stem cell-derived factors promote neurotrophic effects that can mechanistically stimulate nerve regeneration in neurodegenerative diseases and nerve injury. This data collection will enable researchers to gather information to create a precise formulation for future prescribed treatments.
无细胞治疗作为细胞递送的替代方法正在兴起，其利用细胞衍生因子促进内源性再生。本文的目的是系统回顾牙干细胞分泌组对神经再生影响的研究。使用PubMed和Scopus数据库进行检索并选择相关研究。初步检索通过使用关键词确定了36篇文章；然而，只有13篇文章符合既定的纳入标准。13篇文章中的8篇纳入了[具体内容未给出]研究。我们根据牙干细胞衍生分泌组的神经再生潜力进行了分类。所有研究均表明，牙干细胞衍生因子具有神经营养作用，可在神经退行性疾病和神经损伤中通过机制刺激神经再生。这一数据收集将使研究人员能够收集信息，为未来的规定治疗创建精确的配方。
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